Expression of miR-21 in Colorectal Cancer and Its Relationship with Clinicopathological Characteristics of Colorectal Cancer

Jia Lei (Kunming Medical University Haiyuan College)

Abstract


Objective: To investigate the expression of miR-21 in colorectal cancer cells, and to analyze the relationship between the level of miR-21 and the clinicopathological characteristics of colorectal cancer patients. Methods: 210 patients with colorectal cancer treated in our hospital from January 2016 to June 2019 were selected. Cancer tissue specimens (study group) and adjacent normal tissue specimens (control group) were surgically collected, and the quantitative quantitative PCR was used to detect and compare the miR-21 expression of the two groups. Results: The expression of miR-21 in the study group was higher than that in the control group, and the difference was statistically significant (P <0.05). There were significant differences among patients with early and intermediate TNM, patients with low differentiation and patients with moderate to high differentiation, patients with lymph node metastasis and patients without lymph node metastasis, patients with high infiltration and patients with low infiltration, patients with high CEA levels, and patients with low CEA, and the difference was statistically significant (P <0.05). Conclusion: In colorectal cancer, miR-21 is highly expressed, which is closely related to stage and differentiation, and can be used to reflect the patient’s condition.


Keywords


Micro RNA-21; Colorectal cancer; Expression; Clinicopathological characteristics

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References


Hui Chen, Jun Zhan, Siqi Liu. Expression and clinical significance of microRNA-21 and microRNA-143 in colorectal cancer[J] .Contemporary Medicine, 2019, 25 (17):7-10. (in Chinese)

Judiao Chen, Chengzu Wang, Guoping Yuan, et al. Application of combined detection of miR-21, miR-210 and miR-92a in the diagnosis of colorectal cancer[J]. Chinese Journal of Health Laboratory Technology, 2019, 29(10):1194-1195+1198. (in Chinese)



DOI: https://doi.org/10.30564/jams.v3i3.1639

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