Clinical Efficacy and Safety of Joint Butylphthalide and Human Albumin Treatment of PTCI

Authors

  • Jinjian Yang The Graduate School of Xuzhou Medical University
  • Deqin Geng Department of Neurology, Affiliated Hospital of Xuzhou Medical University

DOI:

https://doi.org/10.30564/jams.v1i1.19

Abstract

Objective: To observe the clinical efficacy and safety of butylphthalide joint human albumin in the treatment of the progress of type in acute cerebral infarction(PTCI). Methods: 120 patients with PTCI in Department of Neurology of Shuyang People’s Hospital were used to observe the efficacy. These patients were all treated by routine medicine including anti-platelet, statins, edaravone, ginkgo leaf extract and dipyridamole after admission. According to whether used butylphthalide and(or) human albumin in the treatment of PTCI, the patients were divided into A group 30 cases, B group 45 cases, and C group 45 cases.Patients of group C were given conventional treatment. Group B were given conventional treatment and human albumin injection(5g, ivgtt, qd, 3 days in a course); Group A were treated with butylphthalide (first,with butylphthalide and sodium chloride injection 100ml, ivgtt, for 7d, then with butylphthalide soft capsules 0.2g, tid, for 21d ), human albumin(5g, ivgtt, qd, for 3d) and routine medicine. The change of NIHSS score, Barthel Index, and mRS of three groups respectively during progress,1 week, 2 weeks and 90 days after progress were observed and analyzed. Results: NIHSS score, Barthel Index, and mRS of group A, group B and group C all showed no statistically significant (all p > 0.05) on 1 week after treatment; NIHSS score and mRS of group A were both lower than group B and group C on 2 weeks and 90 days after treatment, and both of them showed statistically significant (p<0.05);  Barthel Index of group A was higher than group B and group C on 90 days after treatment,it showed statistically significant (p<0.05); The total effective rate of group A96.7%> group B88.9%> group C77.8%),showed statistically significant (p<0.05). Conclusions: Butylphthalide joint human albumin treatment of PTCI has good therapeutic effect and safety, it is useful to clinical promotion and further research.

Keywords:

Butylphthalide, Human albumin, PTCI

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