Research Progress of Vitamin D and Pathogenesis of Bronchial Asthma

Authors

  • Zhilu Li First Clinical College, Hainan Medical College
  • Bingxi Xu First Clinical College, Hainan Medical College
  • Yingjing Du First Clinical College, Hainan Medical College
  • Xiaomin Zhuang School of Management, Hainan Medical College
  • Yuxuan Wang School of Public Health, Hainan Medical College
  • Saijia Li First Clinical College, Hainan Medical College
  • Honghai Li First Clinical College, Hainan Medical College
  • Pingping Yan Clinical Skills Center, Hainan Medical College

DOI:

https://doi.org/10.30564/jams.v3i3.2439

Abstract

At present the incidence of bronchial asthma on the rise, its pathogenesis and the genetic immune and the relationship between social environment and other aspects are inseparable the activity of vitamin D (Vit D) in the body in the form of 1, 25 - (OH) 2 d3, mainly involved in bone metabolism and calcium absorption in addition to this, a growing number of studies show that in Vit D plays an important role in the pathogenesis of bronchial asthma, play a role in the immune function of bronchial asthma growth hormone sensitivity adjustment and airway remodeling in this paper, the development of a variety of mechanisms, such as Vit D. Review the possible mechanisms affecting bronchial asthma, hoping to provide adjuvant treatment for patients with bronchial asthma, discover new treatment approaches, and improve the quality of life for patients.

Keywords:

Bronchial asthma, Vitamin D, Pathogenesis

References

[1] AL-DAGHRI N M, AL-ATTAS 0 S, YAKOUT S M, et al. The association of serum 25-0H vitamin D with asthma in Saudi adults [J]. Medicine, 2018(36):e12286.

[2] CHRISTAKOS S,LI S, CRUZJ D L, et al. New developments in our understanding of vitamin metabolism action and treatment [J]. Metabolism, 2019 (01):112- 120.

[3] Zhang Yi, Wang Chong, LIU Jinglei. Progress in the correlation between serum VitD level and lung function in children with bronchial asthma [J].Hainan Medical Science, 2015(17):2265-2268.

[4] SAHOTA. Understanding vitamin D deficiency [J]. Age Ageing, 2014 (05):589-591.

[5] ESFANDIAR N,ALAEI F, FALLAH S,et al. Vitamin D deficiency and its impact on asthma severity in asthmatic children [J]. Ital J Pediatr, 2016 (01):108 - 114.

[6] Huang Chun, Zhou Linying, TAN Liqin, Han Yulan, Wei Hongyan.New progress in pathogenesis and treatment of bronchial asthma in children [J]. Chinese community physicians, 2019(32):6-8+10.

[7] Ramireddy S,Raghuraman P,Khandelwal P,et al. A molecular simulation analysis of vitamin D targets interleukin 13(IL13) as an alternative to mometasone in asthma [J].3 Biotech, 2018(08):373.

[8] Wang Bai, Qiao Hongmei.VitD deficiency and bronchiolitis in children [J]. International Journal of Pediatrics, 2015(03):228-230.

[9] HRAGUCHI Y, TANIDA H, SUGIMOTO M, et al. 1,25 dihydroxyvitamin D3 upregulates functional C-x-C chemokine receptor type 4 expression in human eosinophils [J]. Int Arch Allergy Immunol, 2012(158):51-57.

[10] Zhong H, Zhou XJ, Hong JG. The effects of vitamin D on allergeninduced expression of interleukin-13 and interleukin-17 in cord blood CD4+T cells [J].Iran J Allergy Asthma Immunol, 2014(02):93-97.

[11] Chary AV,Hemalatha R,Murali MV,et al. Association of T-regulatory cells and CD23/CD21 expression with vitamin D in children with asthma [J]. Ann Allergy Asthma Immunology, 2016(05):447-454.

[12] Poon AH, Mahboub B, Hamid Q. Vitamin D deficiency and severe asthma [J]. Pharmacol Ther, 2013 (02):148-155.

[13] ZHAO ST, WANG CZ. Regulatory T cells and asthma [J].J Zhejiang Univ Sci B, 2018 (09):663-673.

[14] FARIAS AS,SPAGNOL GS,BORDEAUX-REGOP,et al.Vitamin D3 induces IDO+tolerogenic DCs and enhances Tregs, reducing the severity of EAE [J].CNS Neurosci Ther, 2013(04):269-277.

[15] PENNAG, AMUCHASTEGUIS, GIARRATANAN, et al.1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells [J].J Immunol, 2007(01):145-153.

[16] Wang W,Liu QB,Jing W.Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells [J].Chinese Journal of Natural Medicines, 2019(04):252-263.

[17] Pfeffer PE,Chen YH,Woszczek G,et al.Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33 [J].J Allergy Clin Immunol,2015(03):824-827.

[18] Yan S,Chen L,Zhao Q,et al.Developmental endothelial locus-1 (Del-1) antagonizes Interleukin-17-mediated allergic asthma [J].Immunol Cell Biol, 2018(05):526-535.

[19] Zhong Jie, Tao Ning, ZHAO Li, He Cheng, Hu Jianping.The expression of SOCS-1 and SOCS-3 in peripheral blood and their relationship with Th17/Treg imbalance in patients with allergic asthma [J].Journal of Doubtful Diseases, 2019(05):462-466+471.

[20] KELLY H W,STERNBERG A L,LESCHER R,et al.Effect of inhaled glucocorticoids in childhood on adult height [J]. N Engl J Med, 2012(10):904-912.

[21] Bonsignore MR,Profita M,Gagliardo R,et al.Advance in asthma pathophysiology:Stepping forward from the Maurizio Vignola experience [J].Eur Respir Rev, 2015(135):30-39.

[22] Ma Xiaoyan.Correlation analysis of corticosteroid resistant asthma response with peripheral blood mitogen cofilin-1 expression [D].Guangzhou: Southern Medical University, 2012.

[23] Cosmi L,Liotta F,Annunziato F.Th17 regulating lower airway disease [J].Curr Opin Allergy Clin Immunol, 2016 (01):1-6.

[24] Chambers ES,Nanzer AM,Pfeffer PE,et al.Distinct endotypes of steroid-resistant asthma characterized by IL-17A（high）and IFN-gamma（high）immunophenotypes:Potential benefits of calcitriol[J]. J Allergy Clin Immunol,2015(03):628-637.

[25] Maltby S,Tay HL,Yang M,et al.Mouse models of severe asthma:Understanding the mechanisms of steroid resistance,tissue remodelling and disease exacerbation [J].Respirology, 2017(05):874-885.

[26] Ji Xiaolin. The effect of vitamin D on the treatment of glucocorticoidresistant chronic rhinosinusitis [D].Taiyuan: Shanxi Medical University, 2018.

[27] Xiong Anji.Effects of different doses of 1,25 (OH) 2D3 on airway inflammation in asthmatic mice and their mechanisms [D]. Luzhou: Luzhou Medical College, 2014.

[28] GINDE A A,MANSBACH J M,CAMARGO C A.Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey [J].Arch Intern Med, 2009 (04):384-390.

[29] BERRY D J, HESKETH K, POWER C, et al. Vitamin D status has a linear association with seasonal infections and lung function in British adults [J].Br J Nutr, 2011(09):1433-1440.

[30] Chen Xi, Hu Chengping. Progress in airway remodeling in bronchial asthma [J]. Medical Clinical Research, 2012(11):2189-2193.

[31] LAI G, WU C, HONG J, et al. 1,25-Dihydroxyvitamin D(3)(1,25-(OH)(2)D(3)) attenuates airway remodeling in a murine model of chronic asthma [J].J Asthma, 2013(02):133-140.

[32] GUPTA A, SJOUKES A, RICHARDS D, et al. Relationship between serum vitamin D,disease severity,and airway remodeling in children with asthma [J].Am J Respir Criti Care Med, 2011(12):1342-1349.

[33] DAMERA G, FOGLE H W, LIM P, et al. Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1 [J]. Br J Pharmacol, 2009(06):1429-1441.

[34] SONG Y, QI H, WU C. Effect of 1,25-(OH)2D3(a vitamin D analogue)on passively sensitized human airway smooth muscle cells [J]. Respirology, 2007(04):486-494.

[35] Qu Jumei. Correlation study between vitamin D and bronchial asthma in children [D].Yan’an University, 2017.

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Vol. 3 , Iss. 3 (July 2020)

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