Research Progress of Vitamin D and Autoimmune Diseases

Authors

  • Saijia Li First Clinical College, Hainan Medical College
  • Zhilu Li First Clinical College, Hainan Medical College
  • Guanlu Li School of International Education, Hainan Medical College
  • Yiyu Cai School of Tropical Medicine and Laboratory Medicine, Hainan Medical College
  • Yuxuan Wang School of Public Health, Hainan Medical College
  • Pingping Yan Clinical Skills Center, Hainan Medical College

DOI:

https://doi.org/10.30564/jams.v3i3.2443

Abstract

As a fat-soluble vitamin, Vitamin D is a necessary hormone to maintain normal physiological activities of the body. In recent years, vitamin D has been considered as a new neuroendocrine-immunomodulatory hormone, and researchers have paid more attention to the study of immune regulatory mechanism. It is not only related to calcium and phosphorus metabolism, bone metabolism and other important metabolic mechanisms of the body, but also closely related to the immune regulation mechanism of the body. Vitamin D deficiency caused by many factors can play a certain role in the development of autoimmune diseases. In this paper, the related mechanisms of vitamin D affecting autoimmune diseases were reviewed, with a view to expound the close correlation between vitamin D and autoimmune diseases, so as to find new diagnosis and treatment approaches for clinical autoimmune diseases and improve the quality of life of patients with autoimmune diseases.

Keywords:

Vitamin D, Immune regulation, Autoimmune diseases

References

[1] Gorman S,Zafir M,Lim EM,et al. High-Dose Intramuscular Vitamin D Provides Long-Lasting Moderate Increases in Serum 25-Hydroxvita-min D Levels and Shorter-Term Changes in Plasma Calcium[J]. JAOAC Int, 2017 (05): 1337-1344.

[2] Kivity S, Agmonlevin N, Zisappl M, et al. Vitamin D and autoimmune thyroid diseases[J]. Cell Mol Immunol, 2011(03): 243-247.

[3] DeMille DM, Piscitelli M, Ocker A, et al. Vitamin D deficiency in the oncology setting[J]. J Community Support Oncol, 2014(01):13-19.

[4] Freedman DM, Looker AC, Chang SC, et al. Prospective study of serum vitamin D and Cancer mortality in the United States[J]. Natl Cancer Inst, 2007(21):1594-1602.

[5] Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmunediseases,cancers and cardiovascular disease[J]. Am J Clin Nutr, 2004(06):1678-1688.

[6] Cigolini M, Iagulli MP,Miconi V, et al. Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients. [J]. Diabetes Care, 2006(03):722-724.

[7] Badenhoop K, Kahles H, Penna-Martinez M. Vitamin D,immune tolerance, and prevention of type 1 diabetes[J]. Curr Diab Rep, 2012(06):635-42.

[8] Pittas AG, Dawson-Hughes B, Li T, et al. Vitamin D and calcium intake in relation to type 2 diabetes in women[J]. Diabetes Care, 2006(03):650-656.

[9] Chen Chao, Liu Zhichao, ZHU Yonggang, et al. Recent progress in vitamin D research[J]. Chinese Journal of Osteoporosis, 2012(10): 1390-1395.

[10] Zhang Aifei,Feng Zhengping. Advances in immune regulation of vitamin D[J]. Chinese Journal of Osteoporosis, 2019(04): 564-569.

[11] Yang Mingchong. Function of vitamin D binding protein in MS disease progression[D]. Shandong University, 2013.

[12] Bai Yu-fen,XU Hong-tao,Yin Tai-yong,et al. Effects of vitamin D on the microenvironment of Tfh cells in Peyer of systemic Lupus erythematosus mice[J]. Medical Information, 2020(13): 49-53.

[13] Yi Xiang-long. Study on the role and mechanism of 1, 25-dihydroxyvitamin D3 in the pathogenesis of Vogt-Xiaoliuharada disease[D]. Sun Yat-sen University, 2011.

[14] Ji Yongjia, Chen Yanxiang. Advances in immunomodulatory effects of Vitamin D and antimicrobial peptides[J]. Contemporary Medicine, 2018(06): 166-169.

[15] Ke W, Sun T, Zhang Y, et al. 25-hydroxyvitamin D serum level in Hashimoto’s thyroiditis,but not grave’s disease is relatively deficient[J]. Endocr J, 2017(06):581-587.

[16] Tamer G, ARIK S, TAMER I,et al. Relative vitamin d insufficiency inhashimoto’s thyroiditis[J]. Thyroid, 2011(08):891-896.

[17] He Jing, Zhang Chunhui, LI Hui, et al. Study on the effect of vitamin D deficiency treatment on autoimmune thyroid disease[J]. Journal of Qiqihar Medical College, 2020(09): 1117-1118.

[18] Han Jun-lin,Sun Jia. Vitamin D and autoimmune thyroid disease[J]. Journal of Endocrinolog

[19] y and Metabolism, 2009(04): 260-263.

[20] Chinese Society of Rheumatology. Guidelines for the diagnosis and treatment of rheumatoid arthritis[J]. Chinese Journal of Rheumatology, 2010(04): 265-270.

[21] Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis[J]. Lancet. 2016(10055):2023-2038.

[22] Wasserman A. Rheumatoid Arthritis: Common Questions About Diagnosis and Manageme Nt[J]. Am Fam Physician, 2018(07):455-462.

[23] Dong Guiying. Genetic risk factors of rheumatoid arthritis based on gene co-expression network[D]. Shandong University, 2018.

[24] Luo Zhiheng, WU Jie, Qi Shanshan, et al. Research progress on the role of vitamin D system in rheumatoid arthritis[J]. Modern Immunology, 2016(05): 420-423.

[25] Tizaoui K, Hamzaoui K. Association between VDR polymorphisms and rheumatoid arthritis disease: Systematic review and updated meta-analysis of case-control studies[J]. Immunobiology, 2015(06):807-16.

[26] Liu ZQ,Li XX, Qiu SQ, et al. Vitamin D contributes to mast cell stabilization[J]. Allergy,2017(08):1184-1192.

[27] Welsh P,Peters MJ,McInnes IB,et al. Vitamin D deficiency is common in patients with RA and linked to disease activity, but circulating levels are unaffected by TNFalpha blockade: results from a prospective cohort study[J]. Annals of the rheumatic diseases,2011(06):1165–1167.

[28] Wang Su Li,Lv Liangjing. Current status of quality of life studies in patients with systemic lupus erythematosus presents both challenges and opportunities[J]. Chinese Journal of Rheumatology, 2018(04): 217-219.

[29] Chen Gan-qiu. 38 cases of systemic lupus erythematosus (sle) clinical analysis[J]. The Chinese and foreign medical research, 2012(30):141-142.

[30] Li Xin,Li Na,Liu Xiu. Study on factors influencing disease uncertainty in patients with systemic lupus erythematosus (SLE) and implementation of humanistic care strategy[J]. Chinese medical ethics,2017(02):206-210.

[31] Zhang Jing,LUO Jing,WANG Jing,et al. Correlation between serum 25(OH)D level and activity in newly diagnosed systemic lupus erythematosus[J]. Chinese Journal of Rheumatology, 2019(01): 36-41.

[32] Bcn- Zvi I,Aranow C,Mankay M,et al. The impact of,vilamin D on dendritic cell function in patients with systemic lupus erythematosus[J]. PLo S One, 2010 (02): 919.

[33] Islam MA,Khandker SS,Alam SS,et al. Vitamin D status in patients with systemic lupus erythematosus(SLE):A systematic review and meta-analysis[J]. Autoimmun Rev. 2019(11):102-392.

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Vol. 3 , Iss. 3 (July 2020)

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