Relationship between CYP2E1 Gene Polymorphism and Anti-tuberculosis Drug-induced Liver Injury

Donglin Zhu (Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University)
Yun Xi (Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University,)
Jieming Dong (Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University)
Fanhua Huang (Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University)
Changzhi Xu (Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University)
Gang Xiao (Department of Laboratory Medicine, The Third Affiliated Hospital of Southern China Medical University)


 Objective: To investigate the relationship between cytochrome P450 E1 (CYP2E1) gene polymorphisms and susceptibility to anti-tuberculosis drug-induced liver damage (ATDLI) in tuberculosis patients in the Chinese Han nationality. Methods: A retrospective analysis was performed on 360 patients with tuberculosis who had liver damage after tuberculosis treatment (case group) and 360 patients with tuberculosis who did not develop liver injury after treatment (control group). MassARRAY were used to detect CYP2E1 gene polymorphisms. Results: In a total of 8 tagged SNP loci selected, the rs8192773 locus failed to pass the test, and therefore, it is not included in subsequent analysis. At the remaining seven SNP sites, the difference in alleles was not statistically significant between the case group and the control group, suggesting that these sites may not be related to liver damage caused by anti-tuberculosis drugs. Three monomer domains were found in the seven tags SNP loci mentioned above. However, it was found that these haplotypes are not closely related to anti-tuberculosis drug-induced liver damage. Conclusion: The CYP2E1 gene polymorphism in the Chinese Han nationality is not related to the occurrence of anti-tuberculosis drug-induced liver injury.


CYP2E1; MassARRAY; Tuberculosis; Liver injury; Genetic polymorphism

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