Latest Advances in the Treatment of Post-stroke Limb Spasm with Botulinum Neurotoxin

Shuhua Chen (Department of Neurology, Yangpu Hospital, Tongji University)
Lingjing Jin (Department of Neurology, Yangpu Hospital, Tongji University)


Objective: To describe the latest progress in the use of botulinum neurotoxin for post-stroke limb spasm. Methods: This paper looks up the relevant research literatures in recent years in PubMed, Web of Science, Springer, Ovid, CNKI, WanFang databases and summarizes them. Results: The latest progress in the use of botulinum neurotoxin for post-stroke limb spasm was studied from the following aspects: the action mechanism of botulinum neurotoxin; efficacy evaluation; injection dose; target muscle selection; guiding technology; combination therapy. Conclusion: Botulinum neurotoxin is the first-line treatment for post-stroke limb spasm. We need to make continuous improvement and progress from the treatment period, injection dose, target muscle selection, guiding technology and efficacy evaluation to improve the quality of life of the majority of post-stroke survivors in China.


Botulinum neurotoxin; Post-stroke limb spasm; Guiding technology; Combination therapy; Efficacy evaluation

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