The Significance of Cytoskeleton System in Tumor Cell Infiltration

Han Yu (Shanxi Academy of Traditional Chinese Medicine)
Likun Liu (Shanxi Provincial Hospital of Traditional Chinese Medicine)
Shulan Hao (Shanxi Provincial Hospital of Traditional Chinese Medicine)


Cytoskeleton system is mainly composed of three kinds of fibrils: microtubules, microfilaments and intermediate filaments. They are a complex network of protein filaments in the cytoplasm of eukaryotic cells. They not only act as scaffolds in cells, but also play an important role in maintaining the movement of cells, participating in the material transport and signal transmission in cells. It is found that the whole cytoskeleton system is closely related to tumor invasion and growth. Therefore, this article reviews the overview of the cytoskeleton system and its significance for tumor cell invasion and growth.


Cytoskeleton system; Tumor cells; Infiltration

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[1] Small JV, Stradal T, Vignal E, Rottner K. The lamellipodium: where motility begins. Trends Cell Biol 2002; 12(3): 112-20.

[2] Chang Fuju, Zhao Qingxia. Application of Intermediate Filament Classification in Tumor Diagnosis[J].Foreign Medicine (Oncology Section),1986(04):193-196.

[3] Lu Yunkun,Xie Shanshan,Zhou Tianhua.Signal regulation mechanism and in vivo functions of microfilaments[J].Chinese Journal of Cell Biology,2019,41(03):387-398.

[4] Iwaya K, Norio K, Mukai K. Coexpression of Arp2 and WAVE2 predicts poor outcome in invasive breast carcinoma. Mod Pathol 2007; 20(3): 339-43.

[5] Huang FK, Han S, Xing B, Huang J, Liu B, Bordeleau F, et al. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. Nat Commun 2015; 6: 7465.

[6] Jayo A, Malboubi M, Antoku S, Chang W, Ortiz- Zapater E, Groen C, et al. Fascin regulates nuclear movement and deforma- tion in migrating cells. Dev Cell 2016; 38(4): 371-83.

[7] Zhang Hongying, Yang Guanghua, Bu Hong, Zhang Jie, Li Shengfu, Guo Lixin. Study on the cytoskeleton of human rhabdomyosarcoma cell lines with different metastatic potential[J].Tumor,2002(04):291-293+258.

[8] Lu Rui, Ke Yang, Lu Guirong, Ning Tao, Liu Weili, Liao Jing, Wang Bing, E Zheng. Study on the structural characteristics of cell microfilaments among cell clones of human gastric cancer cell line BGC-823 with different metastatic ability[J].Acta Anatomy, 1993(04):386-390+455.



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