A Research on the Relationship between Intestinal Flora and Human Longevity

Muzi Cui (Second Clinical College of Hainan Medical university)
Jianhua Wu (First Clinical College of Hainan Medical university)
Yin Zhang (First Clinical College of Hainan Medical university)
Sixing Liu (School of International Nursing, Hainan Medical University)
Shifeng Shuai (School of Clinical, Hainan Medical University)
Liyi Dan (Second Clinical College of Hainan Medical university)
Pingping Yan (Clinical Skills Center of Hainan Medical University)

Article ID: 3770

DOI: https://doi.org/10.30564/jams.v5i1.3770


The exploration of human life and health is advancing with the changes of the times. With the growth of age, the occurrence of chronic diseases of human immunity and organ system is frequent, which has a serious impact on human health. Genes, environment and other random factors determine the outcome of longevity, and intestinal flora is considered to be a decisive factor affecting human health and longevity, mainly because of its huge impact on human immunity, growth and development. The study of the relationship between intestinal flora and longevity is beneficial to improve the health status of the elderly and improve the overall life level of human beings, which has great scientific research value. This review will review the role of intestinal flora in longevity.


Intestinal flora; A long life. Life and health

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[1] Qin, J., Li, R., Raes, J., et al., 2010. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 464(7285), 59-65.

[2] Li, J., Jia, H., Cai, X., et al., 2014. An integrated catalog of reference genes in the human gut microbiome. Nat Biotechnol. 32(8), 834-841.

[3] Zhe Luan, Bin Yan, Gang Sun, 2018. Research progress on longevity and intestinal microecology. Chinese Journal of Gerontology. 3(13), 3321-3323.

[4] Wangjing Tang, Xiangdong Zhu, Rui Shen, et al., 2018. Research progress of ulcerative colitis and intestinal microflora. Journal of Shaanxi University of Traditional Chinese Medicine. 109-114.

[5] Haiyan Cen, Yuqi Zhang, 2018. Research progress on influencing factors related to longevity.Guangxi Medical. 40(12), 1351-1353.

[6] Podolsky, S.H., 2012. Metchnikoff and the microbiome. Lancet. 380(9856), 1810-1811.

[7] Kim, K.A., Jeong, J.J., Yoo, S.Y., et al., 2016. Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice. BMC Microbiol. 16, 9.

[8] Heintz, C., Mair, W., 2014. You are what you host: microbiome modulation of the aging process. Cell. 156(3), 408-411.

[9] Biagi, E., Franceschi, C., Rampelli, S., et al., 2016. Gut microbiota and extreme longevity. Curr Biol. 26(11), 1480-1485.

[10] Öner Özdemir, 2013. Mechanisms of preventative and therapeutic role of probiotics in different allergic and autoimmune disorders. Journal of Immunology. (3), 103-118.

[11] Yang, R.Y., Zhang, F., Jin, J.X., et al., 2020. Research progress on the relationship between diet and intestinal microflora. Chinese Journal of Microecology. 32(9), 113-1117.

[12] Qinm, Q.Q., Miao, J.J., Wang, Sh.Y., et al., 2017. Association between intestinal flora and immunity in middle-aged and aged people by PCR-DGGE. Journal of Hygiene Research. 46(1), 40-45.

[13] Pan, D.D., Qin, H.L., 2018. Advances in the study of innate lymphocytes in intestinal homeostasis and disease.Chinese journal of Microbiology and Immunology. 38(6), 464-467.

[14] Zhang, H., Wang, Y., Chen, H.Y., 2020. Research progress on the role and mechanism of intestinal flora in host immune response. Microbiologica Sinica. 60(4), 629-640.

[15] Nikolaeva, O., Andreeva, A., Altynbekov, et al., 2020. Probiotic drugs impact on the innate immunity factors. Journal of Global Pharma Technology. 12(1), 38-45.

[16] Yang, X.Zh., 2018. Research progress on the relationship between TLR2 and gastrointestinal diseases. Chongqing Medical University.

[17] Wang, Y., 2018. To explore the therapeutic mechanism of Gegenqinlian Decoction in treating T2DM metabolic endotoxemia based on intestinal flora and LPS/TLR-4/NF-κB signaling pathway. Gansu University of Traditional Chinese Medicine.

[18] Wang, D., Wu, H., Liang, X.Y., et al., 2019. Advances in the Application of Intestinal Flora in Anti-Tumor Therapy. Journal of Nutritional Oncology. (2), 59-66.

[19] Zhou, Y.M., Zhao, Sh., Jiang, Y., et al., 2019. Regulatory Function of Buckwheat-Resistant Starch Supplementation on Lipid Profile and Gut Microbiota in Mice Fed with a High‐Fat Diet. Journal of Food Science. 84(9).

[20] Li, X.X., Yu, M.L., Lu, Sh.F., et al., 2017. The role and significance of intestinal microflora and intestinal epithelial cells in type 2 diabetes induced by high fat and high sugar. Chinese Journal of Diabetes. 25(9), 842-846.

[21] Fei, J., Luo, J.T., Zhang, X.Y., et al., 2018. Role of short-chain fatty acids in regulating human energy metabolism by intestinal flora. Chinese Journal of Diabetes. 10(5), 370-373.

[22] Sun, Y., Huang, Y.Ch., Ye, F.H., et al., 2020. Effects of probiotics on glycemic control and intestinal dominant flora in patients with type 2 diabetes mellitus: A protocol for systematic review and meta-analysis. Medicine. 99(46), e23039.

[23] Liu, Ch.G., Shao, W., Gao, M., et al., 2020. Changes in intestinal flora in patients with type 2 diabetes on a low-fat diet during 6 months of follow-up. Experimental and therapeutic medicine. 20(5), 40.

[24] Wang, B.H., 2007. Study on intestinal microbial diversity and its correlation with human metabolism. Zhejiang university.

[25] Gill, S.R., Pop, M., Deboy, R.T., et al., 2006. Metagenomic analysis of the human distal gut microbiome. Science. 312, 1355-1359.

[26] Schloss, P.D., Larger, B.R., Handelsman, J., 2004. Integration of microbial ecology and statistics:a test to compare gent libraries. Appl Environ Microbiol. 70(9), 5485-5492.

[27] Thaiss, C.A., Nobs, S.P., Elinav, E., 2017. NFIL-trating the host circadian rhythm-microbes fine-tune the epithelial clock. Cell Metab. 26(5), 699-700.

[28] Watad, A., Azrielant, S., Bragazzi, N.L., et al., 2017. Seasonality and autoimmune diseases: the contribution the four seasons to the mosaic of autoimmunity. J Autoimmun. 82(6), 13-30.

[29] Heping Zhang, 2019. Probiotics, Gut microbiota and health. Chinese Science Bulletin. 7.

[30] None, 2020. Improving gut flora may prolong life. Hyology. 128.

[31] Shirong Wang, Zhen Tian, Zhuoming Qin, 2014. Discussion on the correlation between intestinal health and longevity. Chinese Journal of Microecology. 26(08), 991-993.

[32] Tiancheng Xu, Lixia Pei, Lu Chen, et al., 2019. Biorhythm phenomenon of bacterial flora and its clinical significance. Medical Schools of Thought Contend. 10(5), 4-7.

[33] Collino, S., Montoliu, I., Martin, F.P., et al., 2013. Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids,amino acids, and gut microbiota metabolism. PLoS One. 8(3), e56564.


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