Association of Genetic Polymorphism of GSTM1 and GSTT1 with the Susceptibility to Antituberculosis Drug-induced Hepatotoxicity in Chinese Population

Donglin Zhu (Department of Laboratory Medicine, The Third Affliated Hospital of Sun Yat-sen University)
Yun Xi (Department of Laboratory Medicine, the Third Affliated Hospital of South China Medical University)
Changzhi Xu (Department of Laboratory Medicine, The Third Affliated Hospital of Sun Yat-sen University)
Biji Zou (Department of Laboratory Medicine, The Third Affliated Hospital of Sun Yat-sen University)
Jing Huang (Department of Laboratory Medicine, the Third Affliated Hospital of South China Medical University)
Hua Li (Department of Laboratory Medicine, the Third Affliated Hospital of South China Medical University)
Gang Xiao (Department of Laboratory Medicine, the Third Affliated Hospital of South China Medical University)

Abstract


Objective To investigate the relationship between the polymorphism of glutathione S transferase M1, T1(GSTM1, GSTT1) gene and the susceptibility to antituberculosis drug induced hepatotoxicity (ATDH) in patients with tuberculosis. Methods GSTM1 and GSTT1 gene polymorphisms in patients with or without liver toxicity after antituberculous treatment were analyzed using multiple PCR method. Results In ATDH group and control group, the proportion of GSTM1 gene deletion was 58.0% and 50.7%respectively, and the difference was not statistically signifcant (OR=1.322, 95%CI=0.921~1.878), the frequencies of GSTT1 deletion were 46.3% and 49.3%, respectively, and there was no signifcant difference between them. There was no signifcant difference in frequency of GSTM1 and GSTT1 variation between case group and control group (P> 0.05), and no synergistic effect of those two gene polymorphism were detected in the occurrence of antituberculosis drug-induced hepatotoxicity. Conclusion The polymorphisms of GSTM1 and GSTT1 genes may not be associated with the risk of ATDH.


Keywords


GSTM1; GSTT1; Tuberculosis; Hepatotoxicity; Genetic Polymorphism

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DOI: https://doi.org/10.30564/jams.v1i3.56

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