Relationship Between Serum Testosterone, Leptin, Interleukin-6 (il-6) Level and Insulin Sensitivity in Non-obese and Obese Male Subjects in Magway Region, Myanmar

Mya Thanda Sein (Department of Physiology University of Medicine 1 , Yangon, Myanmar)
Zarchi Theint-Theint Hlaing (Department of Physiology, University of Medicine, Magway Magway Regional Division, The Republic of Union of Myanmar)
Thurein - Zaw (Department of Physiology, University of Medicine, Magway, Magway Regional Division, The Republic of Union of Myanmar)
Yin Thu Theint (Department of Physiology, University of Medicine 2, Yangon The Republic of Union of Myanmar)
Soe Minn Htway (Department of Physiology, University of Medicine, Magway, Magway Regional Division, The Republic of Union of Myanmar)


Objective: To determine the relationship between insulin resistance and related variables (serum testosterone, interleukin (IL-6) and leptin level) in obese and non-obese healthy subjects.

Methods: Community-based cross-sectional, analytic study was undertaken in 60 subjects for each obese group (BMI ≥ 30.0 kg/m2) and non-obese group (BMI 18.5 to 24.9 kg/m2) (age;18-45 years) residing in Magway Township from December 2016  to December 2017. Serum insulin, testosterone, IL-6 and leptin levels were measured by enzyme linked immunoassay, and serum fasting glucose was measured by glucose oxidase method. Insulin sensitivity was calculated by HOMA formula (Homeostatic Model Assessment).

Results: HOMA-IR, serum leptin and IL-6 level were significantly higher in obese group while serum testosterone level was significantly lower in obese group. There was a significantly correlation between HOMA-IR with leptin (r=0.306, p=0.001), IL-6 (r=0.237, p=0.009) and testosterone (r=-0.209, p=0.02). Moreover, serum leptin was significantly and positively correlated with IL-6 (r=0.391, p<0.001) while serum testosterone was significantly and negatively correlated with leptin (r=-0.408, p<0.001), and IL-6 (r=-0.34, p<0.001).

Conclusions:  Obese men are more likely to have low testosterone, high inflammatory markers leptin and Il-6, which were associated with decreased insulin sensitivity.


Leptin, testosterone, IL-6,HOMA-IR, obesity

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