Effect of Alpha-lipoic Acid on the Corrected QT Interval, QT Dispersion and Spatial QRS-T Angle in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy

Victoria A Serhiyenko (Professor of Danylo Halytsky Lviv National Medical University)
Krystina Kozlovska (Department of endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine)
Alexandr Serhiyenko (Department of endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine)


Objective: The significance of cardiac autonomic neuropathy has not been fully appreciated and there is no unified treatment algorithm. Aim: To investigate the effects of alpha-lipoic acid on the corrected QT interval (QTc), QT dispersion (QTd) and spatial QRS-T angle in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy. Research designs and methods: 33 patients with type 2 diabetes mellitus and definite stage of cardiac autonomic neuropathy were allocated to two treatment groups: control (n=15) received standard antihyperglycaemic therapy; group 2 (n=18) - in addition alpha-lipoic acid 600 mg/d for three months. The QTc interval, QTd and spatial QRS-T angle parameters were analyzed. Results: It was found out that alpha-lipoic acid contributed to decrease of the QTc, QTd and QRS-T angle. Conclusions: The positive influences of alpha-lipoic acid suggests the feasibility of its administration to patients with type 2 diabetes mellitus and definite stage of cardiac autonomic neuropathy. Obtained results suggest that the efficacy of alpha-lipoic acid is the result of its direct effect on the investigated indexes.


Type 2 diabetes mellitus, Cardiac autonomic neuropathy, Alpha-lipoic acid, Corrected QT interval, Spatial QRS-T angle

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DOI: https://doi.org/10.30564/jer.v2i2.2750


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