Predisposition of Obesity Through Genetic and Non Genetic Risk Factors

Alice Jayapradha Cheekurthy (Department of Biochemistry, Maris Stella College (Autonomous), Vijayawada-8,Andhra Pradesh,India)

Abstract


There is an increase in the prevalence of obesity in many counties. This has increased the count of individuals to double, triple, and even quadruple. Obesity is a complex, multifactorial disease, with genetic, behavioral, socioeconomic, and environmental origins, obesity raises the risk of debilitating morbidity and mortality as it is an important predisposition for diabetes. These days it has been reported that it is an important risk factor for COVID-19. The rationale of this case-control observational study is to identify obese individuals among the diabetic and non-diabetic population. The study includes non - genetic factors like lipid profiles with genetic factors in form of SNP as a predisposition factor. The sequencing of the amplified portion of the ADIPOQ gene revealed the presence of SNPs rs2241767 in 46.3% population and showed increased lipid profile values. It can be concluded that these are important predisposing factors for obesity.


Keywords


Obesity, risk factor, Type 2 diabetes mellitus

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DOI: https://doi.org/10.30564/jer.v2i2.2767

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