Predisposition of Obesity through Genetic and Non-Genetic Risk Factors

Alice Jayapradha Cheekurthy (Department of Biochemistry, Maris Stella College (Autonomous), Vijayawada-8, Andhra Pradesh, India)

Article ID: 2767

DOI: https://doi.org/10.30564/jer.v2i2.2767

Abstract


Globally there is an increase in the number of people affected by obesity.This has increased the count of individuals to double,triple, and even quadruple. Obesity is a complex disease that has a genetic, behavioural,socioeconomic, and environmental effect. This raises morbidity and mortality in obesity. It is an important predisposition for diabetes as well as the current pandemic COVID-19. The rationale of this case-control observational study is to identify obese individuals among the diabetic and non-diabetic population. The study includes non - genetic factors like lipid profiles with genetic factors in form of SNP as a predisposition factor. The amplified portion of the ADIPOQ gene sequence revealed the presence of SNPs rs2241767 in 46.3% population and showed increased lipid profile values. It can be concluded that these are important predisposing factors for obesity.


Keywords


Obesity;Risk factor;Type 2 diabetes mellitus

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