Metformin and lactic acidosis in diabetic patients

Baiyan Zhao (The First Clinical College of Hainan Medical University, Haikou 571100, China;)
Zhiwei Zhang (Clinical College of Hainan Medical University, Haikou 571100, China)
Jiaying Sun (The First Clinical College of Hainan Medical University, Haikou 571100, China)
Zhangyi He (The First Clinical College of Hainan Medical University, Haikou 571100, China)
Xinxin Zhou (The First Clinical College of Hainan Medical University, Haikou 571100, China)
Saijia Li (The First Clinical College of Hainan Medical University, Haikou 571100, China)
Zhilu Li (The First Clinical College of Hainan Medical University, Haikou 571100, China)
Pingping Yan (Clinical Skills Center, Hainan Medical University, Hainan Haikou 570100 ,China)

Abstract


 Metformin is the basic drug in the clinical treatment of Diabetes, often used in the treatment of Type 2 Diabetes Mellitus (T2DM), its effect has been fully verified in the clinical treatment of T2DM. However, in the treatment of T2DM with metformin, there is still a certain probability of related lactic acidosis, and the fatality rate is high. Therefore, is the use of metformin drug treatment a direct risk factor for lactic acidosis in diabetic patients? This paper will review the hypoglycemic mechanism of metformin and related studies on lactic acidosis, so as to further explore the relationship between metformin and lactic acidosis in diabetic patients, and provide help and reference for metformin drugs in the clinical treatment of T2DM.


Keywords


Metformin; T2DM; Lactate Acidosis

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DOI: https://doi.org/10.30564/jer.v3i1.2849

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