Evaluation of Genetics of Obesity and Mc4r Deficiency:A Gene-Oriented Approach to Obesity

Onur Oral (Ege University, Faculty of Sports Sciences, Izmir, Turkey)
George Nomikos (Chios Hospital, Department of Orthopaedic Surgery, Chios, Greece)
Nikitas Nomikos (School of Physical Education & Sport Science, National & Kapodistrian University of Athens;Medical School, National & Kapodistrian University of Athens)


Obesity is a multifactorial and complex health problem that is affected by several factors including genetic, environmental, social, behavioural, and biological aspects. Even though the influence of other environmental and behavioural factors such as sedentary lifestyle, high-calorie nutritional intake, the inadequate expenditure of energy are acknowledged as important aspects that cause obesity, the issue of inheritance is indisputable. The study aims to investigate the effects of inheritance on obesity and examine how understanding and detecting genetic reasons behind obesity may benefit the treatment and prevention of the obesity epidemic. The relationship between common gene variants and obesity is now being studied through the emergence of GWAS. It is undeniable that genetic mutations and gene deficiencies particularly MC4R deficiency are significant factors. The process of detecting genes that create a tendency to obesity is currently being studied. It may be possible to prevent and treat obesity with the detection of certain genes. 


Obesity, genetics of obesity, MC4R, mutation

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DOI: https://doi.org/10.30564/jer.v3i1.2977


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