Urinary C-peptide Creatinine Ratio and Its Correlation with Parameters of Metabolic Syndrome

Manoj Gedam (Department of Endocrinology, Guwahati Medical College, Assam, India)
Dipti Sarma (Department of Endocrinology, Guwahati Medical College, Assam, India)
Bipul Choudhury (Department of Endocrinology, Guwahati Medical College, Assam, India)


To assess the correlation between urinary C peptide creatinine ratio with serum C peptide, serum insulin and its correlation with clinical and biochemical parameters of metabolic syndrome. A total of 100 subjects more than 18 years of age with metabolic syndrome according to ATP III criteria with 100 controls were included in a prospective observational study for a period of 1.5 years. Individual parameters of metabolic syndrome was higher in females with hypertriglyceridemia was most common and hyperglycaemia least common parameter of metabolic syndrome. Fasting urinary C peptide creatinine ratio and Stimulated urinary C peptide correlate significantly with fasting serum C peptide (p<0.01),stimulated serum C peptide (p<0.01), serum fasting insulin (p<0.01) and HOMA IR (p<0.01). A fasting urinary C peptide creatinine ratio of more than 1.8 nmol/mmol, stimulated urinary C peptide creatinine ratio more than 2.8 nmol/mmol and HOMA IR >2.7 can be used as a parameter to distinguish individual with and without metabolic syndrome. Urinary C peptide creatinine ratio correlate with serum C peptide and parameters of metabolic syndrome and can be used as a non-invasive simple tool to assess insulin resistance and also to distinguish patients with and without metabolic syndrome.


Metabolic syndrome;Insulin resistance;Body mass index;Type 2 diabetes mellitus

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DOI: https://doi.org/10.30564/jer.v3i2.3451


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