The Role of Vitamin D on Thyroid Antibodies in Patients with Chronic Autoimmune Thyroiditis

Nino Turashvili (Department of Medicine, Ivane Javakhishvili Tbilisi State University)
Lali Javashvili (Cortex Clinic Ltd)
Elene Giorgadze (Ivane Javakhishvili Tbilisi State University, National Institute of Endocrinology)

Article ID: 4408



Vitamin D deficiency is a global problem, which has taken the form of apandemic. Existing data indicate that vitamin D is not only a nutrient. Ithas also a hormone-specific activity. Vitamin D is characterized by antiinflammatory and immunomodulatory properties. Chronic autoimmunethyroiditis is a disease of autoimmune genesis, in which lymphocyticinfiltration gradually destroys thyroid tissue. There are some evidencesabout vitamin D deficiency and the development of chronic autoimmunethyroiditis. The article has reviewed the current literature about the impactand the benefits of vitamin D on thyroid antibodies levels.


Hashimoto’s thyroiditis; Chronic autoimmune thyroiditis; Vitamin D

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[1] D’Aurizio, F., Villalta, D., Metus, P., et al., 2015. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases?. Autoimmunity reviews. 14(5), 363-369.

[2] Holick, M.F., 2007. Vitamin D deficiency. New England journal of medicine. 357(3), 266-281.

[3] Herly, M., Stengaard-Pedersen, K., Vestergaard, P., et al., 2018. The D-vitamin metabolite 1,25(OH)2D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients. Scandinavian journal of immunology. 88(3), e12704.

[4] Infante, M., Ricordi, C., Sanchez, J., et al., 2019. Influence of vitamin D on islet autoimmunity and beta-cell function in type 1 diabetes. Nutrients. 11(9), 2185.

[5] Norris, J.M., Lee, H.S., Frederiksen, B., et al., 2018. Plasma 25-hydroxyvitamin D concentration and risk of islet autoimmunity. Diabetes. 67(1), 146-154.

[6] Lu, M., Taylor, B.V., Körner, H., 2018. Genomic effects of the vitamin D receptor: potentially the link between vitamin D, immune cells, and multiple sclerosis. Frontiers in immunology. 9, 477.

[7] Smolders, J., Damoiseaux, J., 2011. Vitamin D as a T-cell modulator in multiple sclerosis. Vitamins & Hormones. 86, 401-428.

[8] Rolf, L., Muris, A.H., Hupperts, R., et al., 2016. Illuminating vitamin D effects on B cells–the multiple sclerosis perspective. Immunology. 147(3), 275-284.

[9] Ajjan, R.A., Weetman, A.P., 2015. The pathogenesis of Hashimoto’s thyroiditis: further developments in our understanding. Hormone and Metabolic Research. 47(10), 702-710.

[10] Vondra, K., Stárka, L., Hampl, R., 2015. Vitamin D and thyroid diseases. Physiological research. 64, S95.

[11] Antonelli, A., Ferrari, S.M., Corrado, A., et al., 2015. Autoimmune thyroid disorders. Autoimmunity reviews. 14(2), 174-180.

[12] Wacker, M., Holick, M.F., 2013. Sunlight and Vitamin D: A global perspective for health. Dermato-endocrinology. 5(1), 51-108.

[13] Christakos, S., Dhawan, P., Verstuyf, A., et al., 2016. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological reviews. 96(1), 365-408.

[14] Zhu, J., DeLuca, H.F., 2012. Vitamin D 25-hydroxylase–four decades of searching, are we there yet? Archives of biochemistry and biophysics. 523(1), 30- 36.

[15] Nettore, I.C., Albano, L., Ungaro, P., et al., 2017. Sunshine vitamin and thyroid. Reviews in Endocrine and Metabolic Disorders. 18(3), 347-354.

[16] Cesareo, R., Iozzino, M., D’onofrio, L., et al., 2015. Effectiveness and safety of calcium and vitamin D treatment for postmenopausal osteoporosis. Minerva Endocrinologica. 40(3), 231-237.

[17] Bikle, D.D., 2012. Vitamin D and bone. Current osteoporosis reports. 10(2), 151-159.

[18] Bivona, G., Agnello, L., Bellia, C., et al., 2019. Non-skeletal activities of vitamin D: from physiology to brain pathology. Medicina. 55(7), 341.

[19] Wacker, M., Holick, M.F., 2013. Vitamin D—effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 5(1), 111-148.

[20] Zhao, R., Zhang, W., Ma, C., et al., 2021. Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease. Frontiers in Immunology. 12, 352.

[21] Gao, X.R., Yu, Y.G., 2018. Meta-analysis of the association between vitamin D receptor polymorphisms and the risk of autoimmune thyroid disease. International journal of endocrinology.

[22] Drozdenko, G., Scheel, T., Heine, G., et al., 2014. Impaired T cell activation and cytokine production by calcitriol-primed human B cells. Clinical & Experimental Immunology. 178(2), 364-372.

[23] Chambers, E.S., Hawrylowicz, C.M., 2011. The impact of vitamin D on regulatory T cells. Current allergy and asthma reports. 11(1), 29-36.

[24] Jeffery, L.E., Wood, A.M., Qureshi, O.S., et al., 2012. Availability of 25-hydroxyvitamin D3 to APCs controls the balance between regulatory and inflammatory T cell responses. The Journal of Immunology. 189(11), 5155-5164.

[25] Prietl, B., Treiber, G., Pieber, T.R., et al., 2013. Vitamin D and immune function. Nutrients. 5(7), 2502- 2521.

[26] Xie, Z., Chen, J., Zheng, C., et al., 2017. 1, 25-dihydroxyvitamin D3-induced dendritic cells suppress experimental autoimmune encephalomyelitis by increasing proportions of the regulatory lymphocytes and reducing T helper type 1 and type 17 cells. Immunology. 152(3), 414-424.

[27] Mele, C., Caputo, M., Bisceglia, A., et al., 2020. Immunomodulatory effects of vitamin D in thyroid diseases. Nutrients. 12(5), 1444.

[28] Zheng, S.G., Meng, L., Wang, J.H., et al., 2006. Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+ CD25+ cells in the recipient. International immunology. 18(2), 279-289.

[29] Mazokopakis, E.E., Kotsiris, D.A., 2014. Hashimoto’s autoimmune thyroiditis and vitamin D deficiency. Current aspects. Hellenic journal of nuclear medicine. 17(1), 37-40.

[30] Liontiris, M.I., Mazokopakis, E.E., 2017. A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients. Points that need more investigation. Hellenic Journal of Nuclear Medicine. 20(1), 51-56.

[31] Ferrari, S.M., Fallahi, P., Antonelli, A., et al., 2017. Environmental issues in thyroid diseases. Frontiers in endocrinology. 8, 50.

[32] Wiersinga, W.M., 2016. Clinical relevance of environmental factors in the pathogenesis of autoimmune thyroid disease. Endocrinology and Metabolism. 31(2), 213-222.

[33] Muscogiuri, G., Mitri, J., Mathieu, C., et al., 2014. Mechanisms in Endocrinology Vitamin D as a potential contributor in endocrine health and disease. European journal of endocrinology. 171(3).

[34] Lee, H.J., Li, C.W., Hammerstad, S.S., et al., 2015. Immunogenetics of autoimmune thyroid diseases: a comprehensive review. Journal of autoimmunity. 64, 82-90.

[35] Wang, J., Lv, S., Chen, G., et al., 2015. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients. 7(4), 2485-2498.

[36] Ben-Skowronek, I., Szewczyk, L., Kulik-Rechberger, B., et al., 2013. The differences in T and B cell subsets in thyroid of children with Graves’ disease and Hashimoto’s thyroiditis. World Journal of Pediatrics. 9(3), 245-250.

[37] Weetman, A.P., 2021. An update on the pathogenesis of Hashimoto’s thyroiditis. Journal of Endocrinological Investigation. 44(5), 883-890.

[38] Kmieć, P., Sworczak, K., 2015. Vitamin D in thyroid disorders. Experimental and Clinical Endocrinology & Diabetes. 123(07), 386-393.

[39] Tamer, G., Arik, S., Tamer, I., et al., 2011. Relative vitamin D insufficiency in Hashimoto’s thyroiditis. Thyroid. 21(8), 891-896.

[40] Unal, A.D., Tarcin, O., Parildar, H., et al., 2014. Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis. Central-European journal of immunology. 39(4), 493.

[41] Kivity, S., Agmon-Levin, N., Zisappl, M., et al., 2011. Vitamin D and autoimmune thyroid diseases. Cellular & molecular immunology. 8(3), 243-247.

[42] Sayki Arslan, M., Topaloglu, O., Ucan, B., et al., 2015. Isolated vitamin D deficiency is not associated with nonthyroidal illness syndrome, but with thyroid autoimmunity. The Scientific World Journal.

[43] Bozkurt, N.C., Karbek, B., Ucan, B., et al., 2013. The association between severity of vitamin D deficiency and Hashimoto’s thyroiditis. Endocrine Practice. 19(3), 479-484.

[44] Muscogiuri, G., Mari, D., Prolo, S., et al., 2016. 25 hydroxyvitamin D deficiency and its relationship to autoimmune thyroid disease in the elderly. International Journal of Environmental Research and Public Health. 13(9), 850.

[45] Wang, X., Zynat, J., Guo, Y., et al., 2015. Low serum vitamin D is associated with anti-thyroid-globulin antibody in female individuals. International journal of endocrinology.

[46] Choi, Y.M., Kim, W.G., Kim, T.Y., et al., 2014. Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid. 24(4), 655-661.

[47] Kim, C.Y., Lee, Y.J., Choi, J.H., et al., 2019. The Association between Low Vitamin D Status and Autoimmune Thyroid Disease in Korean Premenopausal Women: The 6th Korea National Health and Nutrition Examination Survey, 2013–2014. Korean Journal of Family Medicine. 40(5), 323.

[48] Goswami, R., Marwaha, R.K., Gupta, N., et al., 2009. Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey. British Journal of Nutrition. 102(3), 382-386.

[49] Ma, J., Di Wu, C.L., Fan, C., et al., 2015. Lower serum 25-hydroxyvitamin D level is associated with 3 types of autoimmune thyroid diseases. Medicine. 94(39).

[50] Holick, M.F., Binkley, N.C., Bischoff-Ferrari, H.A., et al., 2011. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology & metabolism. 96(7), 1911-1930.

[51] Krysiak, R., Kowalcze, K., Okopien, B., 2016. The effect of vitamin D on thyroid autoimmunity in non-lactating women with postpartum thyroiditis. European Journal of Clinical Nutrition. 70(5), 637- 639.

[52] Simsek, Y., Cakır, I., Yetmis, M., et al., 2016. Effects of Vitamin D treatment on thyroid autoimmunity. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. pp. 21.

[53] Mazokopakis, E.E., Papadomanolaki, M.G., Tsekouras, K.C., et al., 2015. Is vitamin D related to pathogenesis and treatment of Hashimoto’s thyroiditis. Hellenic Journal of Nuclear Medicine. 18(3), 222-227.

[54] Chaudhary, S., Dutta, D., Kumar, M., et al., 2016. Vitamin D supplementation reduces thyroid peroxidase antibody levels in patients with autoimmune thyroid disease: An open-labeled randomized controlled trial. Indian journal of endocrinology and metabolism. 20(3), 391.

[55] Chahardoli, R., Saboor-Yaraghi, A.A., Amouzegar, A., et al., 2019. Can supplementation with vitamin D modify thyroid autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and thyroid profile (T3, T4, TSH) in Hashimoto’s thyroiditis? A double blind, Randomized clinical trial. Hormone and Metabolic Research. 51(05), 296-301.

[56] Knutsen, K.V., Madar, A.A., Brekke, M., et al., 2017. Effect of vitamin D on thyroid autoimmunity: a randomized, double-blind, controlled trial among ethnic minorities. Journal of the Endocrine Society. 1(5), 470-479.

[57] Safabakhsh, M., Tangestani, H., Saeidifard, N., et al., 2018. Does vitamin D improve the serum level of anti-TPO and anti-TG in Autoimmune thyroid diseases? A systematic review and meta-analysis. Journal of Nutritional Sciences and Dietetics.

[58] Anaraki, P.V., Aminorroaya, A., Amini, M., et al., 2017. Effect of Vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto’s thyroiditis: A double-blind randomized placebo-controlled clinical trial. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences. pp. 22.


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