Factors impacting Catecholamines in Caregivers of Patients with Dementia

Akemi Hirano (Shubun University, Faculty of Nursing)
Yusuke Suzuki (Centre for Community Liaison and Patient Consultations, Nagoya University Hospital, 65 Tsuruma, Showa, Nagoya, Aichi 466-8550, Japan)
Toshio Hayashi (Department of Community and In-Home Nursing, Nagoya University Graduate School of Medicine, School of Health Sciences, Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan)
Koichiro Ina (Department of Internal Medicine, Ina Clinic, 3-111 Hirabari, Tenpaku, Nagoya, Aichi 468-0011, Japan)
Joji Onishi (Department of Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma, Showa, Nagoya, Aichi 466-8550, Japan)

Abstract


Background: Caregivers of dementia patients have significantly higher levels of serum IL-6 and CRP compared to non-caregivers, and the accumulation of everyday stressors reportedly promotes the induction of inflammatory markers. However, few studies have identified factors that affect catecholamine levels in caregivers who experience a combination of physical and mental stress from caregiving.

Purpose: This study aimed to identify physical factors that impact catecholamine levels in caregivers of dementia patients.

Methods: Participants were elderly caregivers living together with elderly Alzheimer’s-type dementia patients. We performed logistic regression analysis, with levels of adrenaline, noradrenaline, and dopamine (indicators of catecholamine) as dependent variables.

Results: Caregiver BMI had a significant impact on adrenaline levels (OR: 0.792; 95%CI: 0.654-0.960) and noradrenaline levels (OR: 1.210; 95%CI: 1.009-1.451), whereas age had a significant impact on dopamine levels (OR: 1.162; 95%CI: 1.019-1.324).

Discussion: While caregiver BMI significantly impacted adrenaline and noradrenaline levels, the mechanism underlying these relationships is unclear. One possibility is that obesity (BMI) and a rise in sympathetic nerve activity contributed to hypertension. Our findings suggest that chronic stress in elderly caregivers may potentially impair the dopaminergic activation system in the brain.

Conclusion: There is a need to identify factors which increase BMI in caregivers. Future studies aimed at gaining a better understanding of the lifestyle habits of caregivers and intervention studies aimed at reducing their BMI are warranted.


Keywords


Age;BMI;Caregiver burden;Catecholamine;Dementia

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References


[1]Schulz R, Beach SR. Caregiving as a risk factor for mortality: the Caregiver

[2]Health Effects Study. JAMA 1999; 282: 2215-2219. doi:10.1001/jama.282.23.2215.

[3]von Kanel R, Dimsdale JE, Adler KA, Patterson TL, Mills PJ, Grant I.

[4]Exaggerated plasma fibrin formation (D-dimer) in elderly Alzheimer caregivers as

[5]compared to noncaregiving controls. Gerontology 2005; 51: 7-13. doi: 10.1159/000081428.

[6]Gouin JP, Glaser R, Malarkey WB, Beversdorf D, Kiecolt-Glaser J. Chronic

[7]stress, daily stressors, and circulating inflammatory markers. Health Psychol

[8]; 31: 264-268. doi: 10.1037/a0025536.

[9]Waring SC, Doody RS, Pavlik VN, Massman PJ, Chan W. Survival among patients

[10]with dementia from a large multi-ethnic population. Alzheimer Dis Assoc Disord

[11]; 19: 178-183. doi: 10.1097/01.wad.0000189033.35579.2d.

[12]Kim Y, Schulz R. Family caregivers’ strains: comparative analysis of cancer

[13]caregiving with dementia, diabetes, and frail elderly caregiving. J Aging

[14]Health 2008; 20: 483-503. doi: 10.1177/0898264308317533.

[15]Schoenmakers B, Buntinx F, Delepeleire J. Factors determining the impact of care-giving on caregivers of elderly patients with dementia. A systematic literature review. Maturitas. 2010 Jun;66(2):191-200. doi: 10.1016/j.maturitas.2010.02.009.

[16]Prenderville JA, Kennedy PJ, Dinan TG, Cryan JF. Adding fuel to the fire: the

[17]impact of stress on the ageing brain. Trends Neurosci. 2015 Jan;38(1):13-25.

[18]doi: 10.1016/j.tins.2014.11.001.

[19]Jung YH, Shin NY, Jang JH, et al. Relationships among stress, emotional intelligence, cognitive intelligence, and cytokines. Medicine (Baltimore) 2019; 98: e15345. doi: 10.1097/MD.0000000000015345.

[20]Ziegler MG, Milic M. Sympathetic nerves and hypertension in stress, sleep

[21]apnea, and caregiving. Curr Opin Nephrol Hypertens. 2017 Jan;26(1):26-30. doi:

[22]1097/MNH.0000000000000288.

[23]Zarit SH, Reever KE, Bach-Peterson J. Relatives of the impaired elderly: correlates of feelings of burden. Gerontologist 1980; 20: 649–655.

[24]Brown MR, Fisher LA. 1.E41. Brain peptide regulation of adrenal epinephrine secretion. Am J Physiol. 1984 Jul;247(1 Pt 1):E41-6. doi: 10.1152/ajpendo.1984.247.

[25]Udelsman R, Goldstein DS, Loriaux DL, Chrousos GP. Catecholamine-

[26]glucocorticoid interactions during surgical stress. J Surg Res. 1987.

[27]Dec;43(6):539-45. doi: 10.1016/0022-4804(87)90128-4.

[28]Naito Y, Fukata J, Tamai S, Seo N, Nakai Y, Mori K, Imura H. Biphasic changes

[29]in hypothalamo-pituitary-adrenal function during the early recovery period after

[30]major abdominal surgery. J Clin Endocrinol Metab. 1991 Jul;73(1):111-7. doi:

[31]1210/jcem-73-1-111.

[32]Weissman C. The metabolic response to stress: an overview and update.

[33]Anesthesiology. 1990 Aug;73(2):308-27. doi: 10.1097/00000542-199008000-00020.

[34]Halter JB, Pflug AE, Porte D Jr. Mechanism of plasma catecholamine increases

[35]during surgical stress in man. J Clin Endocrinol Metab. 1977 Nov;45(5):936-44.

[36]doi: 10.1210/jcem-45-5-936.

[37]Esler M. Assessment of sympathetic nervous function in humans from

[38]noradrenaline plasma kinetics. Clin Sci (Lond). 1982 Mar;62(3):247-54. doi:

[39]1042/cs0620247.

[40]Goyarts E, Matsui M, Mammone T, Bender AM, Wagner JA, Maes D, Granstein RD. Norepinephrine modulates human dendritic cell activation by altering cytokine

[41]release. Exp Dermatol. 2008 Mar;17(3):188-96. doi:

[42]1111/j.1600-0625.2007.00677.x.

[43]Maestroni GJ. Short exposure of maturing, bone marrow-derived dendritic cells

[44]to norepinephrine: impact on kinetics of cytokine production and The development.

[45]J Neuroimmunol. 2002 Aug;129(1-2):106-14. doi: 10.1016/s0165-5728(02)00188-1.

[46]LeBlanc J, Côté J, Jobin M, Labrie A. Plasma catecholamines and

[47]cardiovascular responses to cold and mental activity. J Appl Physiol Respir

[48]Environ Exerc Physiol. 1979 Dec;47(6):1207-11. doi:

[49]1152/jappl.1979.47.6.1207.

[50]Flaa A, Sandvik L, Kjeldsen SE, Eide IK, Rostrup M. Does sympathoadrenal

[51]activity predict changes in body fat? An 18-y follow-up study. Am J Clin Nutr.

[52]Jun;87(6):1596-601. doi: 10.1093/ajcn/87.6.1596.

[53]Masuo K, Kawaguchi H, Mikami H, Ogihara T, Tuck ML. Serum uric acid and

[54]plasma norepinephrine concentrations predict subsequent weight gain and blood

[55]pressure elevation. Hypertension. 2003 Oct;42(4):474-80. doi:

[56]1161/01.HYP.0000091371.53502.D3.

[57]Mauriège P, Klein Kranenbarg WM, Prud'homme D, Lamarche B, Tremblay A,

[58]Bouchard C, Nadeau A, Després JP. Insulin and glucagon responses to adrenaline

[59]infusion in abdominal obese men. Int J Obes Relat Metab Disord. 1996

[60]Jul;20(7):668-76.

[61]Masuo K, Mikami H, Itoh M, Ogihara T, Tuck ML. Sympathetic activity and body

[62]mass index contribute to blood pressure levels. Hypertens Res. 2000

[63]Jul;23(4):303-10. doi: 10.1291/hypres.23.303.

[64]Volkow ND, Logan J, Fowler JS, Wang GJ, Gur RC, Wong C, Felder C, Gatley SJ, Ding YS, Hitzemann R, Pappas N. Association between age-related decline in brain

[65]dopamine activity and impairment in frontal and cingulate metabolism. Am J

[66]Psychiatry. 2000 Jan;157(1):75-80. doi: 10.1176/ajp.157.1.75.

[67]Lavalaye J, Booij J, Reneman L, Habraken JB, van Royen EA. Effect of age and

[68]gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy

[69]volunteers. Eur J Nucl Med. 2000 Jul;27(7):867-9. doi: 10.1007/s002590000279.

[70]Block ML, Hong JS. Chronic microglial activation and progressive dopaminergic

[71]neurotoxicity. Biochem Soc Trans. 2007 Nov;35(Pt 5):1127-32. doi:

[72]1042/BST0351127.

[73]Gao HM, Liu B, Hong JS. Critical role for microglial NADPH oxidase in

[74]rotenone-induced degeneration of dopaminergic neurons. J Neurosci. 2003 Jul

[75];23(15):6181-7. doi: 10.1523/JNEUROSCI.23-15-06181.2003.



DOI: https://doi.org/10.30564/jgm.v3i1.2712

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