Application of Simple Head Cooling Combined with Gangliosides in Neonatal Hypoxic-ischemic Encephalopathy

Zhen Zhan (Department of Pediatrics, Children’s Hospital of Anhui Medical University, Hefei, Anhui, 230051, China)
Huanhuan Cheng (Department of Neonatology, Anhui Provincial Children’s Hospital, Hefei, Anhui, 230051, China)
Xianhong Lin (Department of Neonatology, Anhui Provincial Children’s Hospital, Hefei, Anhui, 230051, China)
Yangyang Meng (Department of Pediatrics, Children's Hospital of Anhui Medical University, Hefei, Anhui, 230051, China)
Liying Dai (Department of Pediatrics, Children's Hospital of Anhui Medical University, Hefei, Anhui, 230051, China)
Hong Zheng (Department of Neonatology, Anhui Provincial Children’s Hospital, Hefei, Anhui, 230051, China)
Qilian Xie (Department of Pediatrics, Children's Hospital of Anhui Medical University, Hefei, Anhui, 230051, China)

Article ID: 2666

Abstract


Objective To investigate the effect of simple head cooling combined with ganglioside therapy on neonatal hypoxic-ischemic encephalopathy (HIE) and its clinical efficacy. Methods A total of 100 children with HIE admitted in the neonatal ward of our hospital from August 2018 to October 2020 were selected as the research objects, and were divided into control group and observation group according to the random number table method, with 50 cases in each group. The control group was treated with gangliosides, and the observation group was treated with simple head cooling combined with gangliosides. Observe and compare the clinical performance improvement time, the level of relevant hematological examination indexes before and after treatment, and the neonatal behavioral neurological assessment (NBNA), clinical efficacy, and adverse reactions. Results The improvement time of convulsions, disturbance of consciousness, pupil changes, hypotonia, and gastrointestinal dysfunction in the observation group was significantly lower than that in the control group (all P<0.001). After treatment, the NSE, IL-6, CK, CK-MB of the two groups of children were significantly lower than before treatment, and the serum calcium and NBNA scores were significantly higher than before treatment, and the decrease or increase in the observation group was significantly higher than that of the control Group (all P<0.001). The total effective rate of treatment of children in the observation group (82.00%) was higher than that of the control group (62.00%) (P<0.05). There were no obvious adverse reactions in both groups. Conclusion The simple head cooling combined with gangliosides in the treatment of HIE can improve the clinical symptoms, blood test index levels, and NBNA scores. The clinical effect is clear and superior to the single use of gangliosides.


Keywords


Hypoxic-ischemic encephalopathy; Newborn; Mild hypothermia; Ganglioside; Curative effect

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References


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DOI: https://doi.org/10.30564/jhp.v2i2.2666

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Copyright © 2021 Zhen Zhan, Huanhuan Cheng, Xianhong Lin, Yangyang Meng, Liying Dai, Hong Zheng, Qilian Xie


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