Research Progress on the Relationship between Polymorphism and SLE of Vitamin D Metabolic Pathway Related Gene

Authors

  • Rui Han First Clinical College of Hainan Medical University, Haikou, Hainan, 570100, China
  • Yuxuan Wang School of Public Health, Hainan Medical University, Haikou, Hainan, 570100, China
  • Guanlu Li School of International Education, Hainan Medical University, Haikou, Hainan, 570100, China
  • Yiyu Cai School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, Hainan, 570100, China
  • Zhilu Li First Clinical College of Hainan Medical University, Hainan Haikou 570100
  • Yaqi Huang College of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, 570100, China
  • Saijia Li First Clinical College of Hainan Medical University, Haikou, Hainan, 570100, China
  • Pingping Yan Clinical Skills Center, Hainan Medical University, Hainan Haikou 570100

DOI:

https://doi.org/10.30564/jhp.v3i1.2852

Abstract

Vitamin D is a class of hormones necessary to maintain normalphysiological activities of the body. A large number of studies have shownthat vitamin D, as a fat-soluble vitamin, is not only related to calcium andphosphorus metabolism, but also closely related to immune regulation,humoral regulation, cell cycle and so on. Systemic Lupus erythema-Tosus(SLE) is a specific autoimmune diffuse connective tissue disease thatcauses tissue and organ damage under the joint action of multiple factorssuch as environment and heredity. Among many factors, the vitamin Dmetabolism pathway gene is particularly important for its influence. Someliterature has shown that the genetic polymorphism of vitamin D metabolicpathway genes is correlated with SLE. Therefore, by referring to relevantliterature, this paper summarized the progress in the research on themechanism of genetic polymorphism of vitamin metabolism pathway genesand the development of SLE.

Keywords:

Vitamin D metabolic pathway, Gene polymorphism, Systemic lupus erythematosus

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