Changes and Significance of Cytokines in Serum of Rabbits with Acute Pulmonary Embolism

Yulong Liang (General Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China)
Jianjing Liang (Hebei University, Baoding, Hebei, 071000, China)
Wenjing Feng (General Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China)
Jinghui Mu (General Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China)

Article ID: 4466

Abstract



Objective:To observe the changes of cytokines in serum of rabbits with acute pulmonary embolism, and to provide scientific basis for clinical treatment of the disease.Methods: The animal models of pulmonary embolism were established in 26 healthy rabbits by autologous thrombus reinfusion and normal saline injection, and the serum levels of cytokines (TNF-α, IL-1β, HGF) in the two groups were monitored by enzyme-linked immunosorbent assay.Results: The expression levels of serum inflammatory cytokines (TNF-α, IL-1β) increased in both groups of rabbits within 1-3 hours of the acute stage of embolism, but the expression levels of serum inflammatory cytokines in experimental group of rabbits with pulmonary embolism caused by thrombosis increased more obviously;There was no significant change in serum HGF of rabbits before and after embolization in group B. The serum HGF content of experimental rabbits at 1h, 3h, 12h, 24h and 48h after embolization was significantly higher than that before embolization.And in the acute stage of embolism (1-12 hours), it showed a gradual upward trend.Conclusion: The expression level of serum growth factor is different in different acute stages of pulmonary embolism. Detecting serum cytokines in rabbits with acute pulmonary embolism is of great reference significance for improving clinical diagnosis.


Keywords


Acute pulmonary embolism; Thrombosis; Rabbit serum; Inflammatory cytokines; Hepatocyte factor

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References


[1] Miao, Y., Li, X.M., 2019. Experimental pathological study of acute pulmonary embolism in rabbits. Animal Husbandry and Veterinary Science: Electronic Edition. (16), 2.

[2] Liang, M.T., Li, Y.B., Yang, Y., et al., 2010. Changes of hepatocyte growth factor in rabbits with acute thrombotic pulmonary embolism. Chinese Journal of Elderly Multiple Organ Diseases. 9(1), 5.

[3] Li, H.Y., Zheng, Y.G., Yang, X.F., et al., 2011.Changes of serum thrombomodulin after acute multiple pulmonary thromboembolism in rabbits. Chinese Journal of Gerontology. 31(15), 2.

[4] Ruan, L.B., Jin, H.Y., Chen, J., 2015. Effect and significance of acute pulmonary embolism on growth differentiation factor -15 in rabbits. China Journal of Modern Medicine. 25(4), 5.



DOI: https://doi.org/10.30564/jim.v11i1.4466

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