Research Progress of the Treatment of PD-1 Immune CheckpointInhibitors in Oral Squamous Cell Carcinoma

Yetao Wang (Department of Hematology and Oncology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, 315000, China; Department of stomatology, Longsai Hospital, Ningbo, Zhejiang, 315200, China)
Suying Qian (Department of Hematology and Oncology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, 315000, China;Ningbo Institute of life and Health industry, University of Chinese Academy of Sciences, Ningbo, Zhejiang, 315200, China;Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang, 315200, China)
Kesang Li (Department of Hematology and Oncology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, 315000, China;Ningbo Institute of life and Health industry, University of Chinese Academy of Sciences, Ningbo, Zhejiang, 315200, China;Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang, 315200, China)

Article ID: 2429

Abstract


Targeted immune checkpoint-based immunotherapy has achieved remarkable success in the treatment of malignant tumors. Immune checkpoint inhibitor-programmed cell death protein 1 (PD-1) antibody opens a new era of immunotherapy for platinum-refractory recurrent/metastatic oral squamous cell carcinoma (OSCC). The overall survival of patients treated with immunological checkpoint inhibitors was significantly prolonged, and the overall incidence of grade 3-4 drug-related adverse events (AEs) occurred was lower; however, there are still some challenges to the PD-1’s application in OSCC clinic treatment. This article is just to briefly highlight the development of such application to date.

Keywords


Anti-PD-1; Immune checkpoint inhibitors; Immunotherapy; Oral squamous cell carcinoma

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References


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DOI: https://doi.org/10.30564/jor.v2i2.2429

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