Research Progress of Anti-tumor Active Ingredients in Dandelion

Authors

  • Jumin Xie Medical college of Hubei Polytechnic University, Xialu district, Guilinbei Road No 16, Huangshi, Hubei, 435003, China;Hubei key laboratory of renal disease occurrence and intervention, Hubei Polytechnic University, Xialu district, Guilinbei Road No 16, Huangshi, Hubei, 435003, China
  • Yudi Huang Medical college of Hubei Polytechnic University, Xialu district, Guilinbei Road No 16, Huangshi, Hubei, 435003, China
  • Qingzhi Wang Medical college of YiChun University, Xuefu Road No 576, Yichun, Jiangxi, 336000, China

DOI:

https://doi.org/10.30564/jor.v2i2.2472

Abstract

As a traditional Chinese herb, dandelion, containing complicated activeingredients which includes polysaccharide, flavonoid, terpene, pigment,phytosterol, coumarin, organic acid and etc, plays significant roles invarious physiological activities in organisms. The active ingredientsgenerally interfere in signal transduction of cancer cells, regulate cellcycle and apoptotic protein expression, inhibit cancer cells proliferationand migration and etc, which effectively restrains tumor developmentand deterioration. This article summarizes the anti-tumor mechanism offive active ingredients in dandelion through paper reading which providesthoughts and references for anti-tumor research.

Keywords:

Dandelion;Anti-tumor;Active ingredients

References

[1] Kinouchi, K., P. Sassone-Corsi. Metabolic rivalry: circadian homeostasis and tumorigenesis[J]. Nat Rev Cancer, 2020.

[2] Barcellos-Hoff, M.H., C. Park, E.G. Wright. Radiation and the microenvironment - tumorigenesis and therapy[J]. Nat Rev Cancer, 2005, 5(11): p. 867-75.

[3] Kim, I.G., Y.S. Lee. Radiation-induced tumorigenesis[J]. J Biochem Mol Biol, 2003, 36(1): 144-8.

[4] Wang, W., W. Zou. Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy[J]. Mol Cell, 2020.

[5] Huang, S., et al. Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy[J]. J Cancer Res Clin Oncol, 2020.

[6] Qu, J., et al. Chimeric antigen receptor (CAR)-T-cell therapy in non-small-cell lung cancer (NSCLC): current status and future perspectives[J]. Cancer Immunol Immunother, 2020.

[7] Huang, M.Y., et al. Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms[J]. Pharmacol Ther, 2020: 107694.

[8] Song, X., et al. Overview of current targeted therapy in gallbladder cancer[J]. Signal Transduct Target Ther, 2020, 5(1): 230.

[9] Zhang, J., et al. Small molecules regulating reactive oxygen species homeostasis for cancer therapy[J]. Med Res Rev, 2020.

[10] Wang, W., H. Zhou, L. Liu. The role of Chinese herbal medicine in the management of adverse drug reactions of leflunomide in treating rheumatoid arthritis[J]. Phytomedicine, 2020, 68: 153136.

[11] Zhai, J., et al. Zhixiong Capsule (ZXC), a traditional Chinese patent medicine, prevents atherosclerotic plaque formation in rabbit carotid artery and the related mechanism investigation based on network pharmacology and biological research[J]. Phytomedicine, 2019, 59: 152776.

[12] Mahfuz, S., X.S. Piao. Application of Moringa (Moringa oleifera) as Natural Feed Supplement in Poultry Diets[J]. Animals (Basel), 2019, 9(7).

[13] Zhang, C., et al. Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study[J]. Int J Mol Sci, 2018, 19(9).

[14] Chen, L.L., et al. Effects of processing adjuvants on traditional Chinese herbs[J]. J Food Drug Anal, 2018, 26(2s): S96-s114.

[15] Parvez, M.K. Natural or Plant Products for the Treatment of Neurological Disorders: Current Knowledge[J]. Curr Drug Metab, 2018, 19(5): 424-428.

[16] Yang, B., et al. Nephrotoxicity and Chinese Herbal Medicine[J]. Clin J Am Soc Nephrol, 2018, 13(10): 1605-1611.

[17] Li, L.C., L.D. Kan. Traditional Chinese medicine for pulmonary fibrosis therapy: Progress and future prospects[J]. J Ethnopharmacol, 2017, 198: 45-63.

[18] Shen, C.Y., et al. Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery[J]. Br J Pharmacol, 2017, 174(11): 1395-1425.

[19] Xiu, L.J., et al. Anticancer effects of traditional Chinese herbs with phlegm-eliminating properties - An overview[J]. J Ethnopharmacol, 2015, 172: 155-61.

[20] Wang, C.Y., X.Y. Bai, C.H. Wang. Traditional Chinesemedicine: a treasured natural resource of anticancer drug research and development[J]. Am J Chin Med, 2014, 42(3): 543-59.

[21] Tao, W., et al. Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease[J]. J Ethnopharmacol, 2013, 145(1): 1-10.

[22] Zhang, T.T., J.G. Jiang. Active ingredients of traditional Chinese medicine in the treatment of diabetes and diabetic complications[J]. Expert Opin Investig Drugs, 2012. 21(11): 1625-42.

[23] Samuels, N., et al. Herbal medicine and epilepsy: proconvulsive effects and interactions with antiepileptic drugs[J]. Epilepsia, 2008, 49(3): 373-80.

[24] Lin, G., et al. Chromatographic analysis of Fritillaria isosteroidal alkaloids, the active ingredients of Beimu, the antitussive traditional Chinese medicinal herb[J]. J Chromatogr A, 2001, 935(1-2): 321-38.

[25] Yang, Y., et al. First Report of Purple Spot on Dandelion in China Caused by Alternaria tenuissima[J]. Plant Dis, 2020.

[26] Ning, W., et al. Karyomorphology research in sevenkinds of dandelion in Northeast[J]. Zhongguo Zhong Yao Za Zhi, 2012, 37(6): 771-6.

[27] Li, H.J., et al. Achene morphology cluster analysis of Taraxacum F. H. Wigg. from northeast China and molecule systematics evidence determined by SRAP[J]. Yao Xue Xue Bao, 2012, 47(8): 1063-9.

[28] Liang, Y., et al. Extraction and isolation of the active ingredients of dandelion and its antifungal activity against Candida albicans[J]. Mol Med Rep, 2020, 21(1): 229-239.

[29] Liu, N., et al. The effects of solid-state fermentation on the content, composition and in vitro antioxidant activity of flavonoids from dandelion[J]. PLoS One, 2020, 15(9): p. e0239076.

[30] Menghini, L., et al. Antiproliferative, protective and antioxidant effects of artichoke, dandelion, turmeric and rosemary extracts and their formulation[J]. Int J Immunopathol Pharmacol, 2010, 23(2): 601-10.

[31] Cheng, H., et al. Cadmium tolerance, distribution, and accumulation in Taraxacum ohwianum Kitam. as a potential Cd-hyperaccumulator[J]. Int J Phytoremediation, 2019, 21(6): 541-549.

[32] Dandelion, in Drugs and Lactation Database (LactMed) [M]. 2006, National Library of Medicine (US): Bethesda (MD).

[33] Kováčik, J., et al. Dandelion is more tolerant to cadmium than to nickel excess[J]. Chemosphere, 2019, 224: 884-891.

[34] Wang, L., et al. Ultrasonic-assisted enzymatic extraction and characterization of polysaccharides from dandelion (Taraxacum officinale) leaves[J]. Int J Biol Macromol, 2019, 126: 846-856.

[35] Sarı, A. and Z. Keçeci. Phytochemical Investigations on Chemical Constituents of Taraxacum bessarabicum (Hornem.) Hand.-Mazz. subsp. bessarabicum (Hornem.) Hand.-Mazz[J]. Iran J Pharm Res, 2019, 18(1): 400-405.

[36] Ivanov, I., et al. GC-MS characterization of n-hexane soluble fraction from dandelion (Taraxacum officinale Weber ex F.H. Wigg.) aerial parts and its antioxidant and antimicrobial properties[J]. Z Naturforsch C J Biosci, 2018, 73(1-2): 41-47.

[37] Yang, K., Y. Zhang. Reversal of heavy metal-induced antibiotic resistance by dandelion root extracts and taraxasterol[J]. J Med Microbiol, 2020, 69(8): 1049-1061.

[38] Wei, S., Q. Zhou, S. Mathews. A newly found cadmium accumulator-Taraxacum mongolicum[J]. J Hazard Mater, 2008, 159(2-3): 544-7.

[39] Sun, Z., et al. Effects of dietary dandelion extracts on growth performance, liver histology, immune-related gene expression and CCl(4) resistance of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀) [J]. Fish Shellfish Immunol, 2019, 88: 126-134.

[40] González-Castejón, M., F. Visioli, and A. Rodriguez-Casado. Diverse biological activities of dandelion[J]. Nutr Rev, 2012, 70(9): 534-47.

[41] Duan, L., et al. Comparison of Bioactive Phenolic Compounds and Antioxidant Activities of Different Parts of Taraxacum mongolicum[J]. Molecules, 2020, 25(14).

[42] Yoon, H.S. C.M. Park. Alleviated Oxidative Damage by Taraxacum officinale through the Induction of Nrf2-MAPK/PI3K Mediated HO-1 Activation in Murine Macrophages RAW 264.7 Cell Line[J]. Biomolecules, 2019, 9(7).

[43] Nguyen, C., et al. Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherapeutic Efficacy, and Reduce Tumour Xenograft Growth In Vivo in Prostate Cancer[J]. Evid Based Complement Alternat Med, 2019, 2019: 2951428.

[44] Sun, Y., et al. Dandelion Extract Alleviated Lipopolysaccharide-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells[J]. Toxins (Basel), 2020, 12(8).

[45] Bao, J., L. Chen, and T. Liu. Dandelion polysaccharide suppresses lipid oxidation in Antarctic krill (Euphausia superba)[J]. Int J Biol Macromol, 2019, 133: 1164-1167.

[46] Guo, H., et al. Physicochemical, Structural, and Biological Properties of Polysaccharides from Dandelion[J]. Molecules, 2019, 24(8).

[47] Ren, F., et al. Dandelion Polysaccharide Exerts Anti-Angiogenesis Effect on Hepatocellular Carcinoma by Regulating VEGF/HIF-1α Expression[J]. Front Pharmacol, 2020, 11: 460.

[48] Lin, L., et al. Antibacterial activity of PEO nanofibers incorporating polysaccharide from dandelion and its derivative[J]. Carbohydr Polym, 2018, 198: 225-232.

[49] Cai, L., et al. Purification, Preliminary Characterization and Hepatoprotective Effects of Polysaccharides from Dandelion Root[J]. Molecules, 2017, 22(9).

[50] Park, C.M., et al. Taraxacum officinale Weber extracts inhibit LPS-induced oxidative stress and nitric oxide production via the NF-κB modulation in RAW 264.7 cells[J]. J Ethnopharmacol, 2011, 133(2): 834-42.

[51] Hu, C., D.D. Kitts. Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells[J]. Mol Cell Biochem, 2004, 265(1-2): 107-13.

[52] Li, X.H., et al. Taraxacum mongolicum extract induced endoplasmic reticulum stress associated-apoptosis in triple-negative breast cancer cells[J]. J Ethnopharmacol, 2017, 206: 55-64.

[53] Zhu, H., et al. Dandelion root extract suppressed gastric cancer cells proliferation and migration through targeting lncRNA-CCAT1[J]. Biomed Pharmacother, 2017, 93: 1010-1017.

[54] Chatterjee, S.J., et al. The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells[J]. Evid Based Complement Alternat Med, 2011, 2011: 129045.

[55] Ovadje, P., et al. Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract[J]. J Ethnopharmacol, 2011, 133(1): 86-91.

[56] Hill, R.A., J.D. Connolly. Triterpenoids[J]. Nat Prod Rep, 2020, 37(7): 962-998.

[57] Esatbeyoglu, T., et al. Sesquiterpene Lactone Composition and Cellular Nrf2 Induction of Taraxacum officinale Leaves and Roots and Taraxinic Acid β-d-Glucopyranosyl Ester[J]. J Med Food, 2017, 20(1): 71-78.

[58] Koo, H.N., et al. Taraxacum officinale induces cytotoxicity through TNF-alpha and IL-1alpha secretion in Hep G2 cells[J]. Life Sci, 2004, 74(9): 1149-57.

[59] Takasaki, M., et al. Anti-carcinogenic activity of Taraxacum plant. II[J]. Biol Pharm Bull, 1999, 22(6): 606-10.

[60] Takasaki, M., et al. Anti-carcinogenic activity of Taraxacum plant. I[J]. Biol Pharm Bull, 1999, 22(6): 602-5.

[61] Sharma, K., R. Zafar. Optimization of methyl jasmonate and β-cyclodextrin for enhanced production of taraxerol and taraxasterol in (Taraxacum officinale Weber) cultures[J]. Plant Physiol Biochem, 2016, 103: 24-30.

[62] Tan, B., et al. Effects of taraxerol and taraxerol acetate on cell cycle and apoptosis of human gastric epithelial cell line AGS[J]. Zhong Xi Yi Jie He Xue Bao, 2011, 9(6): 638-42.

[63] Rao, A.S., et al. A comprehensive review on ethnomedicine, phytochemistry, pharmacology, and toxicity of Tephrosia purpurea (L.) Pers[J]. Phytother Res, 2020.

[64] Bin Sayeed, M.S., S.S. Ameen. Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer[J]. Nutr Cancer, 2015, 67(8): 1214-20.

[65] Sundarraj, S., et al. γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells[J]. J Ethnopharmacol, 2012, 141(3): 803-9.

[66] Hsu, H.F., et al. Typhonium blumei extract inhibits proliferation of human lung adenocarcinoma A549 cells via induction of cell cycle arrest and apoptosis[J]. J Ethnopharmacol, 2011, 135(2): 492-500.

[67] Ling, Y., et al. Isolation and identification of two flavonoids from Taraxacum mongolicum Hand.-Mazz[J]. Zhongguo Zhong Yao Za Zhi, 1999, 24(4): 225-6+256.

[68] Williams, C.A., F. Goldstone, J. Greenham. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale[J]. Phytochemistry, 1996, 42(1): 121-7.

[69] Schütz, K., et al. Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry[J]. Rapid Commun Mass Spectrom,

[70] , 19(2): 179-86.

[71] Khan, H., et al. Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects[J]. Semin Cancer Biol, 2019.

[72] Middleton, E., Jr., C. Kandaswami, T.C. Theoharides. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer[J]. Pharmacol Rev, 2000, 52(4): 673-751.

[73] Birt, D.F., S. Hendrich, W. Wang. Dietary agents in cancer prevention: flavonoids and isoflavonoids[J]. Pharmacol Ther, 2001, 90(2-3): 157-77.

[74] Abotaleb, M., et al. Flavonoids in Cancer and Apoptosis[J]. Cancers (Basel), 2018, 11(1).

[75] Zhang, Z. G.W. Huber. Catalytic oxidation of carbohydrates into organic acids and furan chemicals[J]. Chem Soc Rev, 2018, 47(4): 1351-1390.

[76] Yin, X., et al. Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: Advances and prospects[J]. Biotechnol Adv, 2015, 33(6 Pt 1): 830-41.

[77] Sauer, M., et al. Microbial production of organic acids: expanding the markets[J]. Trends Biotechnol, 2008, 26(2): 100-8.

[78] Shi, S., et al. Chemical constituents from Neo-Taraxacum siphonathum[J]. Zhongguo Zhong Yao Za Zhi, 2009, 34(8): 1002-4.

[79] Ho, H.H., et al. Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-κB activity[J]. Toxicol Appl Pharmacol, 2013, 266(1): 76-85.

[80] Ho, H.H., et al. Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals[J]. Food Chem Toxicol, 2010, 48(8-9): 2508-16.

[81] Yoon, J.Y., et al. Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells[J]. Mol Carcinog, 2016, 55(4): 387-96.

[82] Ohri, S.S., et al. Deletion of the pro-apoptotic endoplasmic reticulum stress response effector CHOP does not result in improved locomotor function after severe contusive spinal cord injury[J]. J Neurotrauma, 2012, 29(3): 579-88.

[83] Díaz, K., et al. Isolation and Identification of Compounds from Bioactive Extracts of Taraxacum officinale Weber ex F. H. Wigg. (Dandelion) as a Potential Source of Antibacterial Agents[J]. Evid Based Complement Alternat Med, 2018, 2018: 2706417.

[84] Wang, H.B. Cellulase-assisted extraction and antibacterial activity of polysaccharides from the dandelion Taraxacum officinale[J]. Carbohydr Polym, 2014, 103: 140-2.

[85] Lee, Y.W., et al. Cross-allergenicity of pollens from the Compositae family: Artemisia vulgaris, Dendranthema grandiflorum, and Taraxacum officinale[J]. Ann Allergy Asthma Immunol, 2007, 99(6): 526-33.

[86] Yang, Y., S. Li. Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence[J]. Oxid Med Cell Longev, 2015, 2015: 619560.

[87] Chen, W., et al. Taraxacum officinale extract ameliorates dextran sodium sulphate-induced colitis by regulating fatty acid degradation and microbial dysbiosis[J]. J Cell Mol Med, 2019, 23(12): 8161-8172.

[88] Yang, H.J., et al. Gastroprotective actions of Taraxacum coreanum Nakai water extracts in ethanol-induced rat models of acute and chronic gastritis[J]. J Ethnopharmacol, 2017, 208: 84-93.

[89] Kim, H.M., et al. Taraxacum officinale restores inhibition of nitric oxide production by cadmium in mouse peritoneal macrophages[J]. Immunopharmacol Immunotoxicol, 1998, 20(2): 283-97.

[90] Colle, D., et al. Antioxidant properties of Taraxacum officinale fruit extract are involved in the protective effect against cellular death induced by sodium nitroprusside in brain of rats[J]. Pharm Biol, 2012, 50(7): 883-91.

[91] Hu, C., D.D. Kitts. Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro[J]. Phytomedicine, 2005, 12(8): 588-97.

[92] Jeon, H.J., et al. Anti-inflammatory activity of Taraxacum officinale[J]. J Ethnopharmacol, 2008, 115(1): 82-8.

[93] Ovadje, P., et al. Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways[J]. Oncotarget, 2016, 7(45): 73080-73100.

[94] Sigstedt, S.C., et al. Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells[J]. Int J Oncol, 2008, 32(5): 1085-90.

[95] Yang, N., et al. Organic acid component from Taraxacum mongolicum Hand.-Mazz alleviates inflammatory injury in lipopolysaccharide-induced acute tracheobronchitis of ICR mice through TLR4/NF-κB signaling pathway[J]. Int Immunopharmacol, 2016, 34: 92-100.

[96] Yang, N., et al. Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4/IKK/NF-κB signal pathway[J]. J Ethnopharmacol, 2016, 194: 395-402.

Downloads

How to Cite

Xie, J., Huang, Y., & Wang, Q. (2020). Research Progress of Anti-tumor Active Ingredients in Dandelion. Journal of Oncology Research, 2(2), 24–30. https://doi.org/10.30564/jor.v2i2.2472

Issue

Article Type

Reviews