CDC20, TOP2A and NEK2 Expression in Esophageal Squamous Cell Carcinoma and Its Clinical Significance

Yanjiao Liu (Handan City First Hospital, Handan, Hebei, 056000, China)
Longying He (Handan City First Hospital, Handan, Hebei, 056000, China)
Qian Zhang (Handan City First Hospital, Handan, Hebei, 056000, China)
Xinglong Zhang (Handan City First Hospital, Handan, Hebei, 056000, China)

Article ID: 2549

Abstract


Objective: to study the expression and clinical significance CDC20,TOP2A, NEK2 esophageal squamous cell carcinoma. Methods: Toselect 70 patients with esophageal squamous cell carcinoma, Between August 2018 - August 2020, All intraoperative pathological specimens,A group -35 cases), Cancer tissue, B group, adjacent tissues), two groups of CDC20, TOP2A, NEK 2 expression were detected and analyzed by immunohistochemistry and semi-quantitative reverse transcription polymerase chain reaction -RT-PcR) assay.Results: the values of CDC20,TOP2A, NEK2 expression level in A group were significantly higher thanthose in B group -P<0.05). The expression level CDC20, TOP2A, NEK2esophageal squamous cell carcinoma was positively correlated with TNMstage and lymphatic metastasis, and negatively correlated with tumordifferentiation. Conclusion: CDC20, TOP2A, NEK2 high expression leveldirectly affects the metastasis, recurrence and prognosis of esophagealsquamous cell carcinoma. The combination of three indexes can accuratelyevaluate the pathological status of patients with esophageal squamous cellcarcinoma and help to judge the prognosis of patients accurately

Keywords


Esophageal squamous cell carcinoma;CDC20;TOP2A;NEK2;Clinical significance

Full Text:

PDF

References


[1] Xiangyang Le, Mengni Yun, Qianbin Li, et al. Progress in the cdc20 of new tumor therapeutic targets[J]. Journal of Pharmacy, 2017, 52(9): 1366-1371.

[2] Yanli Guo, Xiaoliang Liang, Gang Kuang, et al. Screening and validation of key hub genes in esophageal squamous cell carcinoma based on bioinformatics analysis[J]. Chinese Journal of Cancer Biotherapy, 2019, 26(2): 166-172.

[3] Dongsheng Niu. Expression of CDC20, TOP2A, NEK2 in esophageal squamous cell carcinoma and its correlation with I clinicopathological features and prognosis. Journal of Applied Cancer, 10(33): 1579-1581.

[4] Guifang Zhang, Lingxin Meng, Zhaojun Ding. Advances in molecular targeted therapy of esophageal cancer[J]. Chinese Journal of Physicians, 2015(z2): 226-229.



DOI: https://doi.org/10.30564/jor.v2i2.2549

Refbacks

  • There are currently no refbacks.
Copyright © 2020 Author(s)


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.