Research advance on the relationship between Wee1 and tumor genesis and progression

Ying Yin (Binzhou Medical University, No. 346 Guanhai Road, Laishan District, Yantai, Shandong 264003)
Guohua Yu (Yantai Yuhuangding Hospital, No. 20 Yuhuangding East Road, Zhifu District, Yantai, Shandong 264000)

Abstract


In the process of biological genetic information transmission, complete and correct genetic information can make cell mitosis proceed normally. In the development of most tumor cells, G2/M cell cycle checkpoint becomes the key checkpoint in the process of mitosis due to the lack of G1/S cell cycle checkpoint, which mainly depends on the abnormal DNA information blocked by Wee1 protein kinase in G2 phase to enter M phase and prolong the time of G2 phase to complete DNA sequencing So that the normal genetic information can be passed on. Wee1 protein kinase expression is significantly increased in most tumor cells, making it a potential target for tumor therapy.


Keywords


WEE1 protein kinase;Cell cycle;Wee1 kinase inhibitor;The tumor

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References


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DOI: https://doi.org/10.30564/jor.v3i1.2851

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