Postoperative Radiotherapy and N2 Non-small Cell Lung Cancer Prognosis: A Retrospective Study Based on Surveillance, Epidemiology, and End Results Database

Yunbo Zhang (Department of Oncology, Zibo Bashan Wanjie Hospital, Zibo, Shandong, 255213, China)
Liping Zheng (Department of Oncology, Zibo Bashan Wanjie Hospital, Zibo, Shandong, 255213, China)
Junqi Liu (Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450000, China)
Jinqiu Li (Department of Radiotherapy, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, 075000, China)
Jianguang Zhang (Department of Oncology, Zibo Bashan Wanjie Hospital, Zibo, Shandong, 255213, China)
Jingjing Ma (Department of Oncology, Zibo Bashan Wanjie Hospital, Zibo, Shandong, 255213, China)
Yuxiu Song (Department of Oncology, Zibo Bashan Wanjie Hospital, Zibo, Shandong, 255213, China)

Abstract


The purpose of this study is to clarify the significance of postoperative radiotherapy for N2 lung cancer. This study aimed to investigate the effect of postoperative radiotherapy on the survival and prognosis of patients with N2 lung cancer. Data from 12,000 patients with N2 lung cancer were extracted from the Surveillance, Epidemiology, and End Results database (2004-2012). Age at disease onset and 5-year survival rates were calculated. Survival curves were plotted using the Kaplan-Meier method. The univariate log-rank test was performed. Multivariate Cox regression were used to examine factors affecting survival. Patients’ median age was 67 years (mean 66.46 ± 10.03). The 5-year survival rate was 12.55%. Univariate analysis revealed age, sex, pathology, and treatment regimen as factors affecting prognosis. In multivariate analysis, when compared to postoperative chemotherapy, postoperative chemoradiotherapy was better associated with survival benefits (hazard ratio [HR]= 0.85, 95% confidence interval [CI]: 0.813-0.898, P <0.001). Propensity score matching revealed that patients who had received postoperative chemoradiotherapy had a better prognosis than did patients who had received postoperative chemotherapy (HR=0.869, 95% CI: 0.817-0.925, P <0.001). Female patients and patients aged <65 years had a better prognosis than did their counterparts. Patients with adenocarcinoma had a better prognosis than did patients with squamous cell carcinoma. Moreover, prognosis worsened with increasing disease T stage. Patients who had received postoperative chemoradiotherapy had a better prognosis than did patients who had received postoperative chemotherapy. Postoperative radiotherapy was an independent prognostic factor in this patient group.

Keywords


Non-small cell lung cancer; Radiotherapy; Postoperative; Prognosis

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DOI: https://doi.org/10.30564/jor.v3i2.3513

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Copyright © 2021 Yunbo Zhang, Liping Zheng, Junqi Liu, Jinqiu Li, Jianguang Zhang, Jingjing Ma, Yuxiu Song


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