Spectrum of Pediatric Malignancies: An Observational Single Center Study from Western India

Aditi Mittal (Department of Medical oncology , SMS Medical College and attached Hospital, Jaipur, India)
Kanu Neemawat (Department of Pathology, SMS Medical College and attached Hospital, Jaipur, India)
Sandeep Jasuja (Department of Medical oncology , SMS Medical College and attached Hospital, Jaipur, India)
Anushree Chaturvedi (Department of Medical Oncology, Apex Super-specialty Hospital, Varanasi, India)

Article ID: 3645

DOI: https://doi.org/10.30564/jor.v3i2.3645

Abstract


Cancer is a leading cause of death for children and adolescent worldwide. The cure rates in low middle-income countries are dismal (20%) in comparison to high income countries (80%). The first move is to assemble precise data on epidemiology of pediatric cancer across the country and its region wide variation. This study attempts to provide spectrum of pediatric malignancies from a tertiary care hospital in the state of Rajasthan, India. A total of 140 cases were studied retrospectively over a period of two years (April 2018-March 2020). Patients, 0-18 years of age that are diagnosed as a case of malignancy were included in this study. The records of these patients were retrieved and analyzed. Patients were stratified in 4 groups; 0-4 years, 5-9 years, 10-14 years and 15-18 years. Most of the patients fell in 15-18 year group (35.7%), followed by 5-9 year group (28.5%). Majority of cases, 67.8% were male. The male to female ratio is 2.1:1. Leukemia (40%) was the most common malignancy followed by lymphoma, retinoblastoma and malignant bone tumors. Acute lymphoblastic leukemia comprises majority (35/56) of leukemia. Retinoblastoma was predominant malignancy among <5-year children. In all other groups, leukemia was predominant. This study gauges the trend of pediatric malignancies at one of the largest tertiary care hospitals in Rajasthan, which is important in the planning and evaluation of health strategies. As we lack a dedicated pediatric cancer registry, such epidemiological studies play a significant part for this small but distinguished group of patients.

Keywords


Pediatric cancer; Epidemiology; Leukemia; Tertiary health care

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References


[1] E. Steliarova-Foucher, M. Colombet, L.A.G. Ries, F. Moreno, A. Dolya, F. Bray, et al., International incidence of childhood cancer, 2001–10: a population-based registry study, Lancet Oncol. 18 (2017) 719–731, https://doi.org/10.1016/S1470-2045(17) 30186-9.

[2] NCDIR Annual Highlights 2017-2018., (n.d.). http://www.ncdirindia.org/ Downloads/Highlights_2017_18.pdf (accessed November 30, 2019)

[3] Ganguly S, Kinsey S, Bakhshi S. Childhood cancer in India. Cancer Epidemiol. 2021 Apr;71(Pt B):101679. doi: 10.1016/j.canep.2020.101679. Epub 2020 Feb 6. PMID: 32033883.

[4] L. Magrath, E. Steliarova-Foucher, S. Epelman, R.C. Ribeiro, M. Harif, C.-K. Li, R. Kebudi, S.D. Macfarlane, S.C. Howard, Paediatric cancer in low-income and middle-income countries, Lancet Oncol. 14 (2013) e104–e116, https://doi.org/10. 1016/S1470-2045(13)70008-1

[5] Parkin DM, Krama´rova´ E, Draper GJ, et al., editors. International incidence of childhood cancer, volume II. IARC scientific publication no. 144. Lyon: International Agency for Research on Cancer, 1998.

[6] Ries LAG, Smith MA, Gurney JG, et al. Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. NIH publication no. 99-4649. Bethesda: National Cancer Institute, SEER Program, 1999.

[7] Three Year Report of the Population Based Cancer Registries 2009-2011: Report of

[8] PBCRs, National Cancer Registry Programme, Indian Council Medical Research,

[9] Bangalore, 2013 (n.d.).

[10] Satyanarayana L, Asthana S, Labani S P. Childhood cancer incidence in India: a review of population-based cancer registries. Indian Pediatr. 2014 Mar;51(3):218-20

[11] Jussawalla DJ, Yeole BB. Childhood cancer in Greater Bombay. Indian Journal of Cancer 1988; 25: 197-206

[12] Das S, Chakraborty AK, Mukharjee K, Kundu BK, et al. The profile of malignant lesions amongst children in north Bengal. Indian Paediatrics 1994; 31: 1281-85.

[13] Nandakumar A, Anantha N, Appaji L, Swamy K, et al. Descriptive epidemiology of childhood cancers in Bangalore, India. Cancer Causes and Control 1996;7: 405-10.

[14] R Chauhan, A Tyagi, N Verma, M Tyagi et al. Spectrum of Pediatric Malignancies at a Tertiary Care Centre in Western Uttar Pradesh. National journal of laboratory medicine 6 (1), 23-27

[15] Bryan EH, Kenneth F, Barbara N, Meenakshi S. Paediatric solid malignant neoplasms: A comparative analysis. Indian Journal of Pathology and Microbiology 2011; 54 (3): 514-19

[16] Kusumakumary P, Jacob R, Jothirmayi R, Nair MK. Profile of paediatric malignancies: A ten year study. Indian Pediatrics 2000; 37: 1234-38.

[17] R. Khera, S. Jain, R. Lodha, S. Ramakrishnan, Gender bias in child care and child health: global patterns, Arch. Dis. Child. 99 (2014) 369–374,

[18] Maitra A. Diseases of infancy and childhood. In: Kumar V, Abbas AK, Fausto N, Aster JC, editors. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Pennsylvania: Saunders; 2010. p. 447- 83.

[19] Bhalodia JN, Patel MM. Profile of Pediatric Malignancy: A three year study. National J of Community Medicine. 2011;2(1):24- 27.

[20] Pattnaik N, Khan MA, Rao ES, Rao BM. Pediatric malignancies. J Clinic Diagn Res. 2012;6(4):674-77

[21] Jan M, Ahmad S, Rashid I, Quyoom S, Rashid T. Pattern and clinical profile of childhood malignancies in Kashmir, India. JK-Practitioner. 2015;20(1):12-16.

[22] Chaudhuri K, Sinha A, Hati GC, Karmakar R et al. Childhood malignancies at the BS Medical College: A ten year study. Indian J Pathol Microbiol. 2003;46(2):194-96.

[23] Jabeen S, Haque M, Islam MJ, Talukder MH. Profile of pediatric malignancies: A five year study. J Dhaka Med Coll. 2010;19(1): 33-38.

[24] Hazarika M, Krishnatreya M, Bhuyan C, Saikia BJ, Kataki AC, Nandy P, et al. Overview of Childhood Cancers at a Regional Cancer Centre in North-East India. Asian Pac J Cancer Prev. 2014;15(18):7817-19.

[25] Devi S. Pattern of Pediatric Malignancy- 8 year experience. International Journal of Medical and Applied Sciences. 2014; 3(4):208-18.

[26] Spinetta JJ, Masera G, Eden T, et al. Refusal, non-compliance, and abandonment of treatment in children and adolescents with cancer:A report of the SIOPWorking Committee on Psychosocial Issues in Paediatric Oncology Med Pediatr Oncol 2002;38:114–117.

[27] Arora RS, Eden T, Pizer B (2007) The problem of treatment abandonment in children from developing countries with cancer. Pediatric Blood & Cancer 49: 941–946


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