Abound Hepatic Mitosis: Unusual Morphology in the Intrahepatic Cholelithiasis Patient

Yunjun Wang (Deptment of Clinical Medcine, Binzhou Medical University, Yantai, Shandong, China Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China)
Lei Jiang (Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China)
Xiumei Wang (Department of Internal Medicine, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China)
Qingxian Huang (Hepatobiliary Surgery, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China)
Shishou Wu (Deptment of Clinical Medcine, Binzhou Medical University, Yantai, Shandong, China Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China)
Ying Yin (Deptment of Clinical Medcine, Binzhou Medical University, Yantai, Shandong, China Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China)
Jun Wang (Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China)
Xubo Pan (Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China)
Guohua Yu (Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China)

Article ID: 3736

Abstract


To explore the clinicopathological features of abound mitosis of the hepatocytes in intrahepatic cholelithiasis. The clinicopathological data of one case diagnosed as intrahepatic cholelithiasis was collected from Yantai Yuhuangding Hospital and the clinicopathological characters were discussed. A 68-year-old man suffered from the pain in the right upper quadrant and radiology showed multiple stones in the gallbladder and left liver. The images suggested intrahepatic cholelithiasis. The patient received gallbladder and partial hepatectomy. A large number of mitosis was observed and twelve nuclear fissions were found under high magnification, even in some area pathological nuclear fission could be observed in morphology. On the basis of detection in laboratory, the diagnosis of intrahepatic cholelithiasis was made. The patient did not receive any therapy after surgery. The patient was in a good condition after 18 months follow-up. Increased number of hepatic mitosis might be due to the stimulation from stones, hepatic biliary or secondary inflammatory. High index of proliferation should be prevented from the potential misdiagnosis of hepatic tumor.


Keywords


Intrahepatic cholelithiasis; Hepatocyte; Mitosis

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DOI: https://doi.org/10.30564/jor.v4i1.3736

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