Developing of Load-bearing Bones Replacement Based on Cerium Compounds/Nano-hydroxyapatite Composites

Salma Mohamed Naga (National Research Center, Ceramics Department, Dokki, Cairo, Egypt)

Article ID: 4084



The importance of implantable biomaterials is growing up in recent days for modern medicine, especially fixation, replacement, and regeneration of load-bearing bones. Through the past several years, metals, ceramics, polymers, and their composites, have been used for the reconstruction of hard tissues. Special standards such as adequate mechanical and biocompatible properties are required to avoid rejection reactions of the tissues. Recently, a number of novel advanced biomaterials are developed as promising candidates. Amongst those, cerium-based biomaterials acquired attention as a substitution material for hard tissues reconstruction because of cerium antioxidative properties, which enabled it to be used to decrease mediators of inflammation. In addition, the eminent mechanical properties, as well as the perfect chemical and biological compatibilities, make cerium-based biomaterials attractive for biomedical application.


Hard tissue; Load-bearing; Biomaterials

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[1] J.-H. Jang, O. Castano, H.-W. Kim. Electrospun materials as potential platforms for bone tissue engineering, Advanced Drug Delivery Review 61 (12) (2009) 1065-1083.

[2] X. Liu, P. Ma. Polymeric scaffolds for bone tissue engineering, Annals of Biomedecal Engineering 32 (3) (2004) 477-486.

[3] W. Bonfield, M.D. Grynpas, A.E. Tully, J. Bowman, J. Abram. Hydroxyapatite reinforced polyethylene— a mechanically compatible implant material for bone replacement, Biomaterials 2 (3) (1981)185-186.

[4] G. Maccauro, P. Rossi, L. Raffaelli, P. Francesco. Alumina and zirconia ceramic for orthopaedic and dental devices, Biomaterial Application Nanomedicine 1 (2011) 299-308 InTech.

[5] O. Roualdes, M.-E. Duclos, D. Gutknecht, L. Frappart, J. Chevalier, D.J. Hartmann. In vitro and in vivo evaluation of an alumina-zirconia composite for arthroplasty applications, Biomaterials 31 (2010) 2043- 2054.

[6] B.S. Bal, W. Zhu, M. Zanocco, E. Marin, N. Sugano, B.J. McEntire, G. Pezzotti. Reconciling in vivo and in vitro kinetics of the polymorphic transformation in zirconia-toughened alumina for hip joints: I. Phenomenology, Material Science Engineering C 72 (2017) 252-258.

[7] P. Fabbri, C. Piconi, E. Burresi, G. Magnani, F. Mazzanti, C. Mingazzini. Lifetime estimation of a zirco-nia-alumina composite for biomedical applications, Dental Materials 30 (2014) 138-142.

[8] M.G. Faga, A. Vallée, A. Bellosi, M. Mazzocchi, N.N. Thinh, G. Martra, S. Coluccia. Chemical treatment on alumina-zirconia composites inducing apatite formation with maintained mechanical properties, Journal of the European Ceramic Society 32 (2012) 2113-2120.

[9] V. K. Singh, B. R. Reddy. Synthesis and characterization of bioactive zirconia toughened alumina doped with HAp and fluoride compounds. Ceramics International 38 (2012) 5333-5340.

[10] V. Ponnilavan, S. Vasanthavel, M. I. K. Khan, A. Dhayalan, S. Kannan. Structural and bio-mineralization features of alumina zirconia composite influenced by the combined Ca2+ and PO4 3− additions, Material Science Engineering C 98 (2019) 381-391.

[11] X.Zho, J. Zheng, W.Zhang, X. Chen, Z. Gui. Preparation of silicon coated-carbon fiber reinforced HA bio-ceramics for application of load-bearing bone, Ceramics International 46 (6) (2020) 7903-7911.

[12] I. Atkinson, E.M. Anghel, S. Petrescu, A.M. Seciu, L.M. Stefan, O.C. Mocioiu, L. Predoana, M. Voicescu, S. Somacescu, D. Culita, M. Zaharescu. Cerium-containing mesoporous bioactive glasses: Material characterization, in vitro bioactivity, biocompatibility and cytotoxicity evaluation, Microporous Mesoporous Materials 276 (2019) 76-88.

[13] G. Lee, M. Carrillo, J. McKittrick, D.G. Martin, E.A. Olevsky. Fabrication of ceramic bone scaffolds by solvent jetting 3D printing and sintering: Towards load-bearing applications, Additive Manufacturing 33 (2020) 101107.

[14] S.K. Evstropiev, A.V. Karavaeva, K.V. Dukelskii, V.M. Kiselev, K.S. Evstropyev, N.V. Nikonorov, E.V. Kolobkova. Transparent bactericidal coatings based on zinc and cerium oxides, Ceramics International 43 (2017) 14504-14510.

[15] J. D. Weaver, C. L. Stabler. Antioxidant cerium oxide nanoparticle hydrogels for cellular Encapsulation, Acta Biomateriala 16 (2015) 136-144.

[16] L. Zhou, S. Tang, L. Yang, X. Huang, L. Zou, Y. Huang, S. Dong, X. Zhou, X. Yang. Cerium ion promotes the osteoclastogenesis through the induction of reactive oxygen species, Journal of Trace Elements in Medicine and Biology 52 (2019) 126-135.


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